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Editorial
. 2021 Apr 27;6(4):346-349.
doi: 10.1016/j.jacbts.2021.02.010. eCollection 2021 Apr.

The Essential Vulnerability of Human Cardiac Myocytes to SARS-CoV-2

Mitali Das  1 , Michael R Bristow  2 , Mina K Chung  1
Affiliations
Editorial

The Essential Vulnerability of Human Cardiac Myocytes to SARS-CoV-2

Mitali Das et al. JACC Basic Transl Sci. .
No abstract available

Keywords: COVID-19; SARS-CoV-2; cardiomyocytes; myocarditis.

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Conflict of interest statement

Supported by 810959 AHA Covid-19 Rapid Response Research Coordinating Center grant (to Dr. Chung); by AHA Covid-19 Rapid Response Research grants 811960 (to Dr. Bristow) and 814633 (to Dr. Chung); 16SFRN31420008 AHA Strategically Focused Heart Failure Research Network grant (to Dr. Bristow); and by U.S. National Institutes of Health/National Heart, Lung, and Blood Institute grant R01HL111314.The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
See this image and copyright information in PMC

Comment on

  • SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis.
    Bailey AL, Dmytrenko O, Greenberg L, Bredemeyer AL, Ma P, Liu J, Penna V, Winkler ES, Sviben S, Brooks E, Nair AP, Heck KA, Rali AS, Simpson L, Saririan M, Hobohm D, Stump WT, Fitzpatrick JA, Xie X, Zhang X, Shi PY, Hinson JT, Gi WT, Schmidt C, Leuschner F, Lin CY, Diamond MS, Greenberg MJ, Lavine KJ. Bailey AL, et al. JACC Basic Transl Sci. 2021 Apr;6(4):331-345. doi: 10.1016/j.jacbts.2021.01.002. Epub 2021 Feb 26. JACC Basic Transl Sci. 2021. PMID: 33681537 Free PMC article.

References

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    1. Bailey A.L., Dmytrenko O., Greenberg L. Heart tissues and models COVID-19 myocarditis. J Am Coll Cardiol Basic Trans Science. 2021;6:331–345. - PMC - PubMed
    1. Bristow M.R., Zisman L.S., Altman N.L. Dynamic regulation of SARS-Cov-2 binding and cell entry mechanisms in remodeled human ventricular myocardium. J Am Coll Cardiol Basic Trans Science. 2020;5:871–883. - PMC - PubMed
    1. Tucker N.R., Chaffin M., Bedi K.C., Jr. Myocyte-specific upregulation of ACE2 in cardiovascular disease: implications for SARS-CoV-2-mediated myocarditis. Circulation. 2020;142:708–710. - PMC - PubMed
    1. Sharma A., Garcia G., Jr., Wang Y. Human iPSC-derived cardiomyocytes are susceptible to SARS-CoV-2 infection. Cell Rep Med. 2020;1:100052. - PMC - PubMed

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