Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 22;19(4):313-320.
doi: 10.18502/ijrm.v19i4.9057. eCollection 2021 Apr.

Chronic inflammation in polycystic ovary syndrome: A case-control study using multiple markers

Soumik Goswami  1 , Subhadip Choudhuri  2 , Basudev Bhattacharya  2 , Rana Bhattacharjee  1 , Ajitesh Roy  1 , Satinath Mukhopadhyay  1 , Sujoy Ghosh  1 , Subhankar Chowdhury  1
Affiliations

Chronic inflammation in polycystic ovary syndrome: A case-control study using multiple markers

Soumik Goswami et al. Int J Reprod Biomed. .

Abstract

Background: Polycystic ovary syndrome (PCOS) is associated with insulin resistance and elevated risk of cardiovascular disease and diabetes. Chronic inflammation has been observed in PCOS in several studies but there is also opposing evidence and a dearth of research in Indians.

Objective: To estimate chronic inflammation in PCOS and find its relationship with appropriate anthropometric and biochemical parameters.

Materials and methods: Chronic inflammation was assessed in 30 women with PCOS (Group A) and 30 healthy controls (Group B) with highly sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), tumour necrosis factor alpha (TNFα), and platelet microparticles (PMP). In group A, the relationship of chronic inflammation with insulin resistance, waist hip ratio (WHR) serum testosterone, and serum glutamate pyruvate transaminase (SGPT) were examined.

Results: In group A, the hsCRP, TNFα, and PMP were significantly elevated compared to group B. However, IL-6 level was similar between the groups. In group A, PMP showed a significant positive correlation with waist-hip ratio and serum testosterone. IL-6 showed a significant positive correlation with insulin sensitivity and significant negative correlation with insulin resistance and serum glutamate pyruvate transaminase.

Conclusion: PCOS is associated with chronic inflammation and PMP correlates positively with central adiposity and biochemical hyperandrogenism in women with PCOS.

Keywords: C-reactive protein; Inflammation; Interleukin-6; Microparticles.; Tumor necrosis factor; Polycystic ovary syndrome.

PubMed Disclaimer

Conflict of interest statement

There is no conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Ding T, Hardiman PJ, Petersen I, Wang FF, Qu F, Baio G. The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: A systematic review and meta-analysis. Oncotarget 2017; 8: 96351–96358. - PMC - PubMed
    1. Torchen LC. Cardiometabolic risk in PCOS: More than a reproductive disorder. Curr Diab Rep 2017; 17: 137. - PMC - PubMed
    1. Marshall JC, Dunaif A. Should all women with PCOS be treated for insulin resistance? Fertil Steril 2012; 97: 18–22. - PMC - PubMed
    1. Ng NYH, Jiang G, Cheung LP, Zhang Y, Tam CHT, Luk AOY, et al. Progression of glucose intolerance and cardiometabolic risk factors over a decade in Chinese women with polycystic ovary syndrome: A case-control study. PLoS Med 2019; 16: e1002953. - PMC - PubMed
    1. Randeva HS, Tan BK, Weickert MO, Lois K, Nestler JN, Sattar N, et al. Cardiometabolic aspects of the polycystic ovary syndrome. Endocr Rev 2012; 33: 812–841. - PMC - PubMed

LinkOut - more resources