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. 2021 Apr 27:13:25158414211010550.
doi: 10.1177/25158414211010550. eCollection 2021 Jan-Dec.

Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?

Mine Karahan  1 , Leyla Hazar  2 , Seyfettin Erdem  1 , Sedat Ava  1 , Mehmet Emin Dursun  1 , Atılım Armağan Demirtaş  3 , Uğur Keklikçi  1
Affiliations

Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?

Mine Karahan et al. Ther Adv Ophthalmol. .

Abstract

Purpose: We aimed to analyze blood inflammation parameters in patients with age-related macular degeneration (AMD).

Methods: In this retrospective study, patients were divided into three groups: wet-type AMD (n = 60), dry-type AMD (n = 60), and healthy controls (n = 71). The laboratory and demographic data of the patients were analyzed. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were calculated manually.

Results: The mean NLR was 2.26 ± 1.42 in the dry-type AMD group, 3.90 ± 1.65 in the wet-type AMD group, and 1.84 ± 0.61 in the control group (p < 0.001). The mean MLR was 0.30 ± 0.20 in the dry-type AMD group, 0.47 ± 0.31 in the wet-type AMD group, and 0.28 ± 0.14 in the control group (p < 0.001). The mean PLR was 129.31 ± 79.82 in the dry-type AMD group, 156.67 ± 83.99 in the wet-type AMD group, and 135.59 ± 58.68 in the control group (p = 0.101). Receiver operating characteristic (ROC) curve analyses revealed that the area under the curve (AUC) for NLR and MLR was 0.920 and 0.717, respectively, for wet-type AMD. The sensitivity and specificity of NLR for wet-type AMD were 64% and 93%, respectively, whereas MLR was 63% and 75%, respectively.

Conclusion: Simple blood tests revealed that NLR and MLR were significantly higher in patients with wet-type AMD than in patients with dry-type AMD and healthy controls, which implies low-grade inflammation.

Keywords: age-related macular degeneration; monocyte-to-lymphocyte ratio; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio.

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Conflict of interest statement

Conflict of interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Fundus photograph and optical coherence tomography image of wet-type age-related macular degeneration.
Figure 2.
Figure 2.
Fundus photograph and optical coherence tomography image of dry-type age-related macular degeneration.
Figure 3.
Figure 3.
A representative optical coherence tomography image of atrophy due to dry-type age-related macular degeneration.
Figure 4.
Figure 4.
(a) ROC curve analysis of NLR in wet-type AMD patients (AUC for NLR: 0.920, cutoff value: 3.07, sensitivity: 64%, specificity: 93%). (b) ROC curve analysis of MLR in wet-type AMD patients (AUC for MLR: 0.717, cutoff value: 0.31, sensitivity: 63%, specificity: 75%). AMD, age-related macular degeneration; AUC, area under the ROC curve; MLR, monocyte-to-lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; ROC, receiver operating characteristic.
See this image and copyright information in PMC

References

    1. Subramani S, Khor SE, Livingstone BI, et al.. Serum uric acid levels and its association with Age-Related Macular Degeneration (ARMD). Med J Malaysia 2010; 65: 36–40. - PubMed
    1. Bhatt P, Narvekar P, Lalani R, et al.. An in vitro assessment of thermo-reversible gel formulation containing sunitinib nanoparticles for neovascular age-related macular degeneration. AAPS Pharm Sci Tech 2019; 20: 281. - PubMed
    1. Bhatt P, Kelly S, Sutariya V. Nanoscale delivery systems in treatment of posterior ocular neovascularization: strategies and potential applications. Ther Deliv 2019; 10: 737–747. - PubMed
    1. De Jong PTVM. Age-related macular degeneration. N Engl J Med 2006; 355: 1474–1485. - PubMed
    1. Chakravarthy U, Wong TY, Fletcher A, et al.. Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol 2010; 10: 31. - PMC - PubMed

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