Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;21(4):645-653.
doi: 10.1007/s10238-021-00719-7. Epub 2021 May 17.

Single nucleotide polymorphisms of TRAF2 and TRAF5 gene in ankylosing spondylitis: a case-control study

Shanshan Xu #  1   2 , Jiangping Kong #  1   2 , Li Huang #  3 , Huimin Xie  1   2 , Feier Wang  1   2 , Tingting Zhou  1   2 , Xiaoyi Zhang  4 , Lingxiang Yu  1   2 , Shengqian Xu  5 , Faming Pan  6   7
Affiliations

Single nucleotide polymorphisms of TRAF2 and TRAF5 gene in ankylosing spondylitis: a case-control study

Shanshan Xu et al. Clin Exp Med. 2021 Nov.

Abstract

Objective To investigate the role of eight locus polymorphisms of tumor necrosis factor receptor-associated factor 2 (TRAF2) and TRAF5 gene and their interaction in the susceptibility to ankylosing spondylitis (AS) in Chinese Han population. Methods Eight single nucleotide polymorphisms (SNPs) of TRAF2 (rs3750511, rs10781522, rs17250673, rs59471504) and TRAF5 (rs6540679, rs12569232, rs4951523, rs7514863) gene were genotyped in 673 AS patients and 687 controls. Results The SNPs of TRAF2 and TRAF5 do not indicate a correlation with the susceptibility of AS in Chinese Han population. Genotype frequencies of rs3750511 were statistically significant in females between patients and controls. The allele frequencies of rs10781522 and genotype frequencies of rs3750511 were statistically significant between groups of different diseases activity. One three-locus model, TRAF2 (rs10781522, rs17250673) and TRAF5 (rs12569232), had a maximum testing accuracy of 52.67% and a maximum cross-validation consistency (10/10) that was significant at the level of P = 0.0001, after determined empirically by permutation testing. As to environmental variables, only marginal association was found between sleep quality and AS susceptibility. Conclusion TRAF2 rs3750511 polymorphism may be associated with the susceptibility and severity of AS. Besides, the interaction of TRAF2 and TRAF5 genes may be associated with AS susceptibility, but many open questions remain.

Keywords: Ankylosing spondylitis; Gene–gene interaction; Single nucleotide polymorphisms; TRAF2; TRAF5.

PubMed Disclaimer

References

    1. Baeten D, Baraliakos X, Braun J, et al. Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2013;382:1705–13. https://doi.org/10.1016/s0140-6736(13)61134-4 . - DOI - PubMed
    1. Ng SC, Liao Z, Yu DT, Chan ES, Zhao L, Gu J. Epidemiology of spondyloarthritis in the People’s Republic of China: review of the literature and commentary. Semin Arthritis Rheum. 2007;37:39–47. https://doi.org/10.1016/j.semarthrit.2007.01.003 . - DOI - PubMed
    1. Zhai J, Rong J, Li Q, Gu J. Immunogenetic study in Chinese population with ankylosing spondylitis: are there specific genes recently disclosed? Clin Dev Immunol. 2013. https://doi.org/10.1155/2013/419357 . - DOI - PubMed - PMC
    1. Boonen A. A review of work-participation, cost-of-illness and cost-effectiveness studies in ankylosing spondylitis. Nat Clin Pract Rheumatol. 2006;2:546–53. https://doi.org/10.1038/ncprheum0297 . - DOI - PubMed
    1. Miao J, Chen Y, Zhang B, et al. Surgical treatment for odontoid fractures in patients with long-standing ankylosing spondylitis: a report of 3 cases and review of the literature. World Neurosurg. 2018;116:88–93. https://doi.org/10.1016/j.wneu.2018.05.055 . - DOI - PubMed

Substances

LinkOut - more resources