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Review
. 2021 Dec;18(12):2157-2167.
doi: 10.1080/15476286.2021.1922009. Epub 2021 May 17.

Novel insights into the roles of tRNA-derived small RNAs

Qiyu Pan  1 , Tingting Han  1 , Guoping Li  1
Affiliations
Review

Novel insights into the roles of tRNA-derived small RNAs

Qiyu Pan et al. RNA Biol. 2021 Dec.

Abstract

tRNA-derived small RNA (tsRNA) is a novel class of non-coding RNA that is usually produced from tRNA following endonuclease cleavage which occurs under stress conditions. There are two types of tsRNAs: tRNA-derived fragments (tRFs) and stress-induced tRNA halves (tiRNAs), which differ in their cleavage position. Many studies have demonstrated that tsRNAs are involved in various physiological and pathological processes apart from cancer and gene expression. In this review, we briefly described the biogenesis, classification, and characteristics of tsRNAs and summarized the current research progress of tsRNAs in metabolic diseases, senescence, reproduction, stress, and organ injury, and finally put forward some problems to be solved.

Keywords: metabolic diseases; reproduction; senescence; tRNA derived small RNAs.

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

Figures

Figure 1.
Figure 1.
tsRNAs species and biogenesis
Figure 2.
Figure 2.
tsRNAs take part in various metabolic diseases (Created with Servier Medical Art, https://smart.servier.com)
Figure 3.
Figure 3.
tsRNAs participate in diseases related to senescence (Created with Servier Medical Art, https://smart.servier.com)
Figure 4.
Figure 4.
tsRNAs participate in stress in different forms (Created with Servier Medical Art, https://smart.servier.com)
Figure 5.
Figure 5.
tsRNAs are associated with multiple organs injuries (Created with Servier Medical Art, https://smart.servier.com)
See this image and copyright information in PMC

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