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Review
. 2021 Oct;64(10):1602-1611.
doi: 10.1007/s11427-020-1874-6. Epub 2021 May 13.

AFAP1-AS1: a rising star among oncogenic long non-coding RNAs

Fang Xiong  1   2   3 , Kunjie Zhu  4 , Su Deng  1 , Hongbin Huang  1 , Liting Yang  2 , Zhaojian Gong  5 , Lei Shi  5 , Yi He  4 , Yanyan Tang  4 , Qianjin Liao  4 , Jianjun Yu  4 , Xiaoling Li  3 , Yong Li  6 , Guiyuan Li  3 , Zhaoyang Zeng  3 , Wei Xiong  3 , Shanshan Zhang  7 , Can Guo  8
Affiliations
Review

AFAP1-AS1: a rising star among oncogenic long non-coding RNAs

Fang Xiong et al. Sci China Life Sci. 2021 Oct.

Abstract

Long non-coding RNAs (lncRNAs) have become a hotspot in biomedical research. This interest reflects their extensive involvement in the regulation of the expression of other genes, and their influence on the occurrence and development of a variety of human diseases. Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1) is a recently discovered oncogenic lncRNA. It is highly expressed in a variety of solid tumors, and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs, or by the direct binding to other proteins. Ultimately, AFAP1-AS1 promotes proliferation, chemotherapy resistance, and resistance to apoptosis, maintains stemness, and enhances invasion and migration of tumor cells. This paper summarizes the research concerning AFAP1-AS1 in malignant tumors, including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors. We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research. AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules.

Keywords: AFAP1-AS1; PD-1; anti-cancer drug; immunotherapy; metastasis; proliferation.

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References

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