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Meta-Analysis
. 2021 Aug;40(3):180-185.
doi: 10.1080/10641955.2021.1921792. Epub 2021 May 17.

Does multiple sclerosis increase the risk of preeclampsia? A systematic review and meta-analysis

Ahmed Arafa  1   2 , Xiaowen Wang  1 , Jia-Yi Dong  1 , Ehab S Eshak  1   3
Affiliations
Free article
Meta-Analysis

Does multiple sclerosis increase the risk of preeclampsia? A systematic review and meta-analysis

Ahmed Arafa et al. Hypertens Pregnancy. 2021 Aug.
Free article

Abstract

Objective: We investigated, via systematic review and meta-analysis, whether multiple sclerosis (MS) is associated with the risk of preeclampsia (PE).Methods: From the eligible studies, we pooled odds ratios (ORs) and confidence intervals (CIs) of PE for pregnant women with MS compared with pregnant women without it using the fixed-effects model. The I2 measured heterogeneity between studies.Results: Eight eligible studies (9 cohorts) were included. Pregnant women with MS had no excess risk of PE compared with pregnant women without MS (pooled OR = 0.99, 95% CI: 0.89, 1.09; I2 = 0.00%).Conclusion: MS is not associated with PE.

Keywords: Meta-analysis; multiple sclerosis; preeclampsia; systematic review.

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