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. 2021 Sep;40(9):2507-2512.
doi: 10.1109/TMI.2021.3081066. Epub 2021 Aug 31.

1.7-Micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions-A Feasibility Study

Yan Li, Raksha Sreeramachandra Murthy, Yirui Zhu, Fengyi Zhang, Jianing Tang, Joseph N Mehrabi, Kristen M Kelly, Zhongping Chen

1.7-Micron Optical Coherence Tomography Angiography for Characterization of Skin Lesions-A Feasibility Study

Yan Li et al. IEEE Trans Med Imaging. 2021 Sep.

Abstract

Optical coherence tomography (OCT) is a non-invasive diagnostic method that offers real-time visualization of the layered architecture of the skin in vivo. The 1.7-micron OCT system has been applied in cardiology, gynecology and dermatology, demonstrating an improved penetration depth in contrast to conventional 1.3-micron OCT. To further extend the capability, we developed a 1.7-micron OCT/OCT angiography (OCTA) system that allows for visualization of both morphology and microvasculature in the deeper layers of the skin. Using this imaging system, we imaged human skin with different benign lesions and described the corresponding features of both structure and vasculature. The significantly improved imaging depth and additional functional information suggest that the 1.7-micron OCTA system has great potential to advance both dermatological clinical and research settings for characterization of benign and cancerous skin lesions.

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Figures

Fig. 1.
Fig. 1.
Schematic of the 1.7-micron OCTA system.
Fig. 2.
Fig. 2.
Scanning protocol.
Fig. 3.
Fig. 3.
Healthy human palm. (a) 3D OCT image. (b) Depth encoded angiogram where red to green represents shallow to deep depths. (c) Co-registered OCT image and angiogram projection on Y-X plane. (d)-(k) Cross-sectional OCT images on Y-Z plane from different positions along X direction. DEJ: dermal-epidermal junction, indicated by green dashed line. Scale bar: 1mm.
Fig. 4.
Fig. 4.
Solar lentigo. (a) 3D OCT image. (b) Depth encoded angiogram where red to green represents shallow to deep depths. (c) Co-registered OCT image and angiogram projection on Y-X plane. (d)-(k) Cross-sectional OCT images on Y-Z plane from different positions along X direction. DEJ: dermal-epidermal junction, indicated by green dashed line. Scale bar: 1mm.
Fig. 5.
Fig. 5.
Seborrheic keratosis. (a) 3D OCT image. (b) Depth encoded angiogram where red to green represents shallow to deep depths. (c) Co-registered OCT image and angiogram projection on Y-X plane. (d)-(k) Cross-sectional OCT images on Y-Z plane from different positions along X direction. DEJ: dermal-epidermal junction, indicated by green dashed line. Scale bar: 1mm.
Fig. 6.
Fig. 6.
Cherry angioma. (a) 3D OCT image. (b) Depth encoded angiogram where red to green represents shallow to deep depths. (c) Co-registered OCT image and angiogram projection on Y-X plane. (d)-(k) Cross-sectional OCT images on Y-Z plane from different positions along X direction. DEJ: dermal-epidermal junction, indicated by green dashed line. White dashed box: angioma. Red dashed box: normal tissue. Scale bar: 1mm.
Fig. 7.
Fig. 7.
Dermal nevus. (a) 3D OCT image. (b) Depth encoded angiogram where red to green represents shallow to deep depths. (c) Co-registered OCT image and angiogram projection on Y-X plane. (d)-(k) Cross-sectional OCT images on Y-Z plane from different positions along X direction. DEJ: dermal-epidermal junction, indicated by green dashed line. Scale bar: 1mm. White dashed box: dermal nevus. Red dashed box: normal skin.
Fig. 8.
Fig. 8.
Actinic keratosis. (a) 3D OCT image. (b) Depth encoded angiogram where red to green represents shallow to deep depths. (c) Co-registered OCT image and angiogram projection on Y-X plane. (d)-(k) Cross-sectional OCT images on Y-Z plane from different positions along X direction. DEJ: dermal-epidermal junction, indicated by green dashed line. Scale bar: 1mm.
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