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Comment
. 2021 May 15;81(10):2586-2587.
doi: 10.1158/0008-5472.CAN-21-0885.

The Panorama of Cancer Genetics

Joel S Bader  1
Affiliations
Comment

The Panorama of Cancer Genetics

Joel S Bader. Cancer Res. .

Abstract

Cancer, a disease of the genome, is caused by a combination of germline predisposing variants and acquired somatic mutations. A unified view of heritable and acquired genetic factors will improve our understanding of cancer occurrence and progression. Fanfani and colleagues provide new insight into heritable cancer risk through a computational method that identifies genes and loci that contribute strongly to cancer heritability; many of these loci also harbor somatic drivers. Beyond improving cancer clinical outcomes, these methods will also be valuable across complex disorders by identifying regions responsible for missing heritability.See related article by Fanfani et al., p. 2588.

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest

JSB is a founder and director of Neochromosome, Inc., and serves on the scientific advisory board of AI Therapeutics, Inc.

Comment in

  • The Landscape of the Heritable Cancer Genome.
    Fanfani V, Citi L, Harris AL, Pezzella F, Stracquadanio G. Fanfani V, et al. Cancer Res. 2021 May 15;81(10):2588-2599. doi: 10.1158/0008-5472.CAN-20-3348. Epub 2021 Mar 17. Cancer Res. 2021. PMID: 33731442

Comment on

  • The Landscape of the Heritable Cancer Genome.
    Fanfani V, Citi L, Harris AL, Pezzella F, Stracquadanio G. Fanfani V, et al. Cancer Res. 2021 May 15;81(10):2588-2599. doi: 10.1158/0008-5472.CAN-20-3348. Epub 2021 Mar 17. Cancer Res. 2021. PMID: 33731442

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