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Case Reports
. 2021 Aug;100(2):461-463.
doi: 10.1016/j.kint.2021.04.035. Epub 2021 May 15.

Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine

Vivette D D'Agati  1 , Satoru Kudose  2 , Andrew S Bomback  3 , Ananea Adamidis  4 , Albert Tartini  4
Affiliations
Case Reports

Minimal change disease and acute kidney injury following the Pfizer-BioNTech COVID-19 vaccine

Vivette D D'Agati et al. Kidney Int. 2021 Aug.
No abstract available

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Figures

Figure 1
Figure 1
(a) Light microscopy shows a histologically unremarkable glomerulus (hematoxylin and eosin, original magnification ×400). (b) A low-power view shows diffuse cortical acute tubular injury with focal shedding of degenerating epithelial cells into the lumen (hematoxylin and eosin, original magnification ×200). (c) Electron microscopy demonstrates complete podocyte foot process effacement (original magnification ×8000). To optimize viewing of this image, please see the online version of this article at www.kidney-international.org.
Figure 2
Figure 2
Temporal trends in serum creatinine (mg/dl), serum albumin (g/dl), and proteinuria (g/d if 24-hour sample, g/g if spot sample) are graphed over the first 5 weeks after vaccination.
See this image and copyright information in PMC

Comment in

References

    1. Lebedev L., Sapojnikov M., Wechsler A. Minimal change disease following the Pfizer-BioNTech COVID-19 vaccine. Am J Kidney Dis. 2021;78:142–145. - PMC - PubMed
    1. Kielstein J.T., Termühlen L., Sohn J., Kliem V. Minimal change nephrotic syndrome in a 65-year-old patient following influenza vaccination. Clin Nephrol. 2000;54:246–248. - PubMed
    1. Gutiérrez S., Dotto B., Petiti J.P. Minimal change disease following influenza vaccination and acute renal failure: just a co-incidence? Nefrologia. 2012;32:414–415. - PubMed