Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434

Pengyun Mou¹, Qingbo Zhang², Jing Peng³, Xiaodong Jiang³, Liping Zhang², Zhongbo Zhou⁴, Changsheng Zhang⁵, Yiguang Zhu⁶

Affiliations

¹ College of Life Science, Tarim University/Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, Alar 843300, China; Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
² Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No.1119, Haibin Rd, Nansha District, Guangzhou 511458, China.
³ Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
⁴ College of Life Science, Tarim University/Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, Alar 843300, China. Electronic address: zzb7855@163.com.
⁵ Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No.1119, Haibin Rd, Nansha District, Guangzhou 511458, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
⁶ Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No.1119, Haibin Rd, Nansha District, Guangzhou 511458, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China. Electronic address: ygzhu@scsio.ac.cn.

PMID: 34000328
DOI: 10.1016/j.fitote.2021.104937

Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434

Pengyun Mou et al. Fitoterapia. 2021 Jul.

. 2021 Jul:152:104937.

doi: 10.1016/j.fitote.2021.104937. Epub 2021 May 15.

Authors

Pengyun Mou¹, Qingbo Zhang², Jing Peng³, Xiaodong Jiang³, Liping Zhang², Zhongbo Zhou⁴, Changsheng Zhang⁵, Yiguang Zhu⁶

Affiliations

¹ College of Life Science, Tarim University/Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, Alar 843300, China; Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
² Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No.1119, Haibin Rd, Nansha District, Guangzhou 511458, China.
³ Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
⁴ College of Life Science, Tarim University/Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, Alar 843300, China. Electronic address: zzb7855@163.com.
⁵ Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No.1119, Haibin Rd, Nansha District, Guangzhou 511458, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
⁶ Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No.1119, Haibin Rd, Nansha District, Guangzhou 511458, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China. Electronic address: ygzhu@scsio.ac.cn.

PMID: 34000328
DOI: 10.1016/j.fitote.2021.104937

Abstract

Five new phenylspirodrimanes, stachybomycins A - E (1-5), together with four known compounds (6-9), were isolated from the marine-derived fungus Stachybotrys sp. SCSIO 40434. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and HRESIMS. The absolute configuration of 1 was confirmed by single crystal X-ray diffraction analysis. Compounds 5 and 7 showed moderate antibacterial activities against Micrococcus luteus, Staphylococcus aureus and methicillin resistant Staphylococcus aureus with minimal inhibition concentration (MIC) values of 8, 16 and 16 μg mL^-1, respectively.

Keywords: Antibacterial activity; Marine-derived fungus; Phenylspirodrimane; Stachybotrys sp..

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Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434

Affiliations

Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434

Authors

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Abstract

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Medical