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. 2021 Jul:108:45-52.
doi: 10.1016/j.ijid.2021.05.024. Epub 2021 May 14.

Clinical presentation, outcomes and factors associated with mortality: A prospective study from three COVID-19 referral care centres in West Africa

Marie Jaspard  1 , Mamadou Saliou Sow  2 , Sylvain Juchet  1 , Eric Dienderé  3 , Beatrice Serra  1 , Richard Kojan  4 , Billy Sivahera  4 , Caroline Martin  4 , Moumouni Kinda  4 , Hans-Joerg Lang  4 , Fodé Bangaly Sako  2 , Fodé Amara Traoré  2 , Eudoxie Koumbem  4 , Halidou Tinto  5 , Adama Sanou  6 , Apoline Sondo  7 , Flavien Kaboré  8 , Joseph Donamou  9 , Jean-Paul-Yassa Guilavogui  4 , Fanny Velardo  10 , Brice Bicaba  11 , Olivier Marcy  10 , Augustin Augier  4 , Sani Sayadi  4 , Armel Poda  12 , Sakoba Keita  13 , Xavier Anglaret  1 , Denis Malvy  14 ; COVISTA study group
Affiliations

Clinical presentation, outcomes and factors associated with mortality: A prospective study from three COVID-19 referral care centres in West Africa

Marie Jaspard et al. Int J Infect Dis. 2021 Jul.

Abstract

Objectives: The overall death toll from COVID-19 in Africa is reported to be low but there is little individual-level evidence on the severity of the disease. This study examined the clinical spectrum and outcome of patients monitored in COVID-19 care centres (CCCs) in two West-African countries.

Methods: Burkina Faso and Guinea set up referral CCCs to hospitalise all symptomatic SARS-CoV-2 carriers, regardless of the severity of their symptoms. Data collected from hospitalised patients by November 2020 are presented.

Result: A total of 1,805 patients (64% men, median age 41 years) were admitted with COVID-19. Symptoms lasted for a median of 7 days (IQR 4-11). During hospitalisation, 443 (25%) had a SpO2 < 94% at least once, 237 (13%) received oxygen and 266 (15%) took corticosteroids. Mortality was 5% overall, and 1%, 5% and 14% in patients aged <40, 40-59 and ≥60 years, respectively. In multivariable analysis, the risk of death was higher in men (aOR 2.0, 95% CI 1.1; 3.6), people aged ≥60 years (aOR 2.9, 95% CI 1.7; 4.8) and those with chronic hypertension (aOR 2.1, 95% CI 1.2; 3.4).

Conclusion: COVID-19 is as severe in Africa as elsewhere, and there must be more vigilance for common risk factors such as older age and hypertension.

Keywords: COVID-19; Comorbidities; Mortality; SARS-Cov-2; Sub-Saharan Africa.

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Figures

Figure 1
Figure 1
Kaplan Meier estimate of the probability of clinical worsening and death in the overall population.
Figure 2
Figure 2
Kaplan Meier estimate of the probability of clinical worsening and death, according to sex, age, and comorbidities.
Figure 2
Figure 2
Kaplan Meier estimate of the probability of clinical worsening and death, according to sex, age, and comorbidities.
See this image and copyright information in PMC

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