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. 2021 Jul-Aug;96(4):502-504.
doi: 10.1016/j.abd.2021.02.002. Epub 2021 May 15.

Comparison of cardiotoxicity between N-methyl-glucamine and miltefosine in the treatment of American cutaneous leishmaniasis

Daniel Holanda Barroso  1 , Ciro Martins Gomes  2 , Antônia Marilene da Silva  2 , Raimunda Nonata Ribeiro Sampaio  3
Affiliations

Comparison of cardiotoxicity between N-methyl-glucamine and miltefosine in the treatment of American cutaneous leishmaniasis

Daniel Holanda Barroso et al. An Bras Dermatol. 2021 Jul-Aug.
No abstract available

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Comment in

  • No evidence for cardiotoxicity of miltefosine.
    Dorlo TPC. Dorlo TPC. An Bras Dermatol. 2022 Jul-Aug;97(4):548-549. doi: 10.1016/j.abd.2022.03.002. Epub 2022 May 30. An Bras Dermatol. 2022. PMID: 35654652 Free PMC article. No abstract available.

References

    1. Ministério da Saúde, Departamento de Vigilância Epidemiológica . Ministério da Saúde; Brasília: 2017. Manual de Vigilância e Controle da Leishmaniose Tegumentar Americana atualizada.
    1. Antezana G., Zeballos R., Mendoza C., Lyevre P., Valda L., Cardenas F. Electrocardiographic alterations during treatment of mucocutaneous leishmaniasis with meglumine antimoniate and allopurinol. Trans R Soc Trop Med Hyg. 1992;86:31–33. - PubMed
    1. Sampaio R.N.R., Martins Netto E., Faria E.A., Sampaio J.H.D., Freitas L.C.F., Marsden P.D. Sudden death caused by glucantine. An Bras Dermatol. 1988;63:35–37.
    1. Soto J., Soto P. Miltefosine: oral treatment of leishmaniasis. Expert Rev Anti Infect Ther. 2006;4:177–185. - PubMed
    1. Sundar S., Olliaro P.L. Miltefosine in the treatment of leishmaniasis: clinical evidence for informed clinical risk management. Ther Clin Risk Manag. 2007;3:733–740. - PMC - PubMed

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