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Case Reports
. 2022 Oct-Dec;44(4):595-597.
doi: 10.1016/j.htct.2021.02.006. Epub 2021 May 7.

TCRAD rearrangement in B-cell precursor leukemia: an unexpected finding

Wellington F da Silva  1 , Maria Gabriella Cordeiro  2 , Renata K Kishimoto  3 , Elvira Deolinda Rodrigues Pereira Velloso  2
Affiliations
Case Reports

TCRAD rearrangement in B-cell precursor leukemia: an unexpected finding

Wellington F da Silva et al. Hematol Transfus Cell Ther. 2022 Oct-Dec.
No abstract available

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Figures

Fig. 1
Figure 1
A: peripheral smear (original × 1000; Leishman stain); B: blasts in red and T-lymphocytes in blue by flow cytometry; C: conventional karyotype, G-banding; D and E: metaphasic FISH with TCRAD dual-color break-apart probe; F: metaphasic FISH with MYC dual-color break-apart probe. Note that D, E and F represent the same metaphase and the 5′ signal of TCRAD (Figure 1E) is located near the position of MYC gene in Figure 1F, suggesting TCRAD-MYC translocation. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
See this image and copyright information in PMC

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References

    1. Moorman A V. The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia. Blood Rev [Internet] 2012;26(3):123–135. https://linkinghub.elsevier.com/retrieve/pii/S0268960X12000021 Available from: - PubMed
    1. Cauwelier B., Dastugue N., Cools J., Poppe B., Herens C., De Paepe A., et al. Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRβ locus rearrangements and putative new T-cell oncogenes. Leukemia [Internet] 2006;20(7):1238–1244. http://www.nature.com/articles/2404243 Available from: - PubMed
    1. Cigudosa J.C., Calasanz M.J., Gullón A., Prósper F., Cuesta B., Rifón J., et al. A new case of acute lymphoblastic leukemia B-cell type with chromosomal rearrangements involving the T-cell receptor breakpoint at band 14q11. Am J Hematol [Internet] 1992;41(2):137–139. http://doi.wiley.com/10.1002/ajh.2830410213 Available from: - DOI - PubMed
    1. Duro D., Bernard O., Della Valle V., Leblanc T., Berger R., et al. Inactivation of the P16/INK4/MTS1 Gene by a Chromosome Translocation t(9;14)(p21–22;q11) in an acute lymphoblastic leukemia of B-Cell Type. Cancer Res [Internet] 1996;56(4) http://cancerres.aacrjournals.org/content/56/4/848.abstract 848 LP–854Available from: PMID: 8631023. - PubMed
    1. Zerrouki R., Benhassine T., Bensaada M., Lauzon P., Trabzi A. The complex translocation (9;14;14) involving IGH and CEBPE genes suggests a new subgroup in B-lineage acute lymphoblastic leukemia. Genet Mol Biol [Internet] 2016;39(1):7–13. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000... Available from: - PMC - PubMed

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