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Comment
. 2021 May 17;6(1):196.
doi: 10.1038/s41392-021-00617-0.

Cellular tropism and antigenicity of mink-derived SARS-CoV-2 variants

Li Zhang #  1 , Qianqian Li #  1 , Jianhui Nie  1 , Ruxia Ding  1 , Haixin Wang  1 , Jiajing Wu  1 , Xuguang Li  2 , Xiaoming Yang  3 , Weijin Huang  4 , Youchun Wang  5
Affiliations
Comment

Cellular tropism and antigenicity of mink-derived SARS-CoV-2 variants

Li Zhang et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The cells were infected with an equal amount of 11 pseudoviruses. The luminescence activity was analyzed 24 h after the infection. The mean ratio of the RLU values of mink-derived variant to the reference strain (D614G) was calculated and presented in a–d. a Infection of human cell line by the mink variants. b Infection of monkey cell line by the mink variants. c Infection of reference strain (D614G) in different ACE2 over-expressed 293T cells. d Infection of reference and ten variants in 14 different ACE2 over-expressed 293T cells (heatmaps). e Antigenicity analysis of the mink mutants in 17 monoclonal antibodies (heatmaps). f Antigenicity analyses of mink variants with polyclonal antibodies (heatmaps). CS denotes: convalescent plasma, H: horse, G: goat M: mouse. Data represent the ratio of variants/D614G in EC50 (e, f). The red and blue boxes indicate the increase or decrease of the infectivity (d) or neutralization activity (e, f) as shown in the scale bar. Three to six times experiment results were included
See this image and copyright information in PMC

Comment on

References

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