[Physiologically adequate experimental model of aggression and emotional stress]

Abstract

A simple adequate experimental model of aggression and emotional stress has been elaborated, based on mild fixation of rats tails in the cage wall. It is shown that in a group of rats, in these conditions a continuous aggressive behaviour arises, leading to the development of emotional stress. The elaborated experimental model has no defects, characteristic of other models of aggression and stress. It demands neither a prolonged training of animals nor special expensive equipment; it allows simultaneous use in experiments of a great number of animals, creates conditions for natural aggressive-defensive behaviour of rats without provoking artificial manipulations. The proposed model allows to study the pathogenesis of emotional stress, mechanisms of resistivity and predisposition to it and also search and testing of biologically active substances, enhancing resistance to emotional stress.