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. 2021 Aug;166(8):2255-2261.
doi: 10.1007/s00705-021-05084-0. Epub 2021 May 18.

Phylogenetic analysis of classical swine fever virus isolates from China

Xiaofu Zhu #  1 , Mingjie Liu #  2 , Xujin Wu  3 , Wentao Ma  2 , Xuanduo Zhao  4
Affiliations

Phylogenetic analysis of classical swine fever virus isolates from China

Xiaofu Zhu et al. Arch Virol. 2021 Aug.

Abstract

Classical swine fever (CSF), caused by classical swine fever virus (CSFV), is a severe disease that causes huge economic losses in the swine industry worldwide. In China, CSF has been under control due to extensive vaccination since 1954. However, there are still sporadic CSF outbreaks in China. Here, we isolated 27 CSFV strains from three Chinese provinces (Shaanxi, Gansu, and Ningxia) from 2011 to 2018. Phylogenetic analysis based on the full-length envelope glycoprotein E2 coding region revealed that 25 out of 27 CSFV isolates clustered within subgroups 2.1 and 2.2, while two strains from Gansu belonged to subgroup 1.1. The sequence identity among these 27 isolates varied from 79.3% to 99.8% (nucleotides) and from 83.1% to 99.7% (amino acids). Further analysis based on the E2 amino acid sequences showed that these new isolates have consistent amino acid substitutions, including R31K and N34S.

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