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Comment
. 2021 May 17;56(10):1361-1362.
doi: 10.1016/j.devcel.2021.04.024.

Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis

Chan Choo Yap  1 , Bettina Winckler  2
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Free article
Comment

Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis

Chan Choo Yap et al. Dev Cell. .
Free article

Abstract

Niemann-Pick is a lysosomal storage disease caused by loss of the lysosomal cholesterol exporter NPC1 and leads to axon degeneration. Roney et al. report that immature autophagosomes accumulate in axons because cholesterol-laden lysosomes in the soma are not transported to the axon for autophagosome fusion and maturation because they aberrantly sequester non-functioning kinesin-1.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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