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Review
. 2021 Feb 20;48(2):107-114.
doi: 10.1016/j.jgg.2021.02.006. Epub 2021 Mar 15.

COVID-19 mRNA vaccines

Qingrui Huang  1 , Jiawei Zeng  2 , Jinghua Yan  3
Affiliations
Review

COVID-19 mRNA vaccines

Qingrui Huang et al. J Genet Genomics. .

Abstract

The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines. Taking substantial advantages of versatility and rapid development, two mRNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive results. In this review, we outline keynotes in mRNA vaccine development, discuss recently published data on COVID-19 mRNA vaccine candidates, focusing on those in clinical trials and analyze future potential challenges.

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Figures

Fig. 1
Fig. 1
Schematic representation of mRNA-lipid nanoparticle complex.
Fig. 2
Fig. 2
Antigens of COVID-19 mRNA vaccines. A: Schematic representation of full-length SARS-CoV-2 S primary structure colored by domain. SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; CTD, C-terminal domain; FP, fusion peptide; HR1, heptad repeat 1; CH, central helix; CD, connector domain; HR2, heptad repeat 2; TM, transmembrane domain; CT, cytoplasmic tail. B: The structure of SARS-CoV-2 wild-type S protein in prefusion state (PDB:6XR8). C: The structure of SARS-CoV-2 wild-type S protein in postfusion state (PDB:6XRA). D: The structure of SARS-CoV-2 S-2P (PDB:6VSB). E: The structure of SARS-CoV-2 RBD (PDB:6LZG).
See this image and copyright information in PMC

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