Renal tissue oxygenation after caffeine administration in preterm neonates

Abstract

Background: Caffeine has been associated with reduced rates of acute kidney injury (AKI) in preterm neonates. The effect of caffeine on preterm neonatal renal regional saturation of oxygen (RrSO₂) is unknown.

Methods: RrSO₂ was recorded continuously in neonates < 32 weeks' gestation until 7 days of age with INVOS™ neonatal near-infrared spectroscopy (NIRS) sensors. Baseline RrSO₂ values were established by averaging the saturations in the 20 min prior to caffeine administration. Subgroup analysis was performed based on pre-caffeine RrSO₂ averages. Change in RrSO₂ was recorded at 0.5, 1, 2, 3, 4, 6, and 12 h after maintenance caffeine administration.

Results: Of 35 eligible neonates, 31 (median gestational age 28.4 weeks) received 156 caffeine doses (median 8 mg/kg). Analysis of combined doses showed no significant changes in RrSO₂ after caffeine administration at any time. However, neonates with baseline 20-29.9% had significant increases from 1 to 12 h (range of increase 5.9-13.9%), and those with baseline 30-39.9 had significant increases at 1 h (8.06%, p < 0.05).

Conclusions: Maintenance caffeine dosing increased RrSO₂ in neonates with low RrSO₂ in the first week. Further research is needed to determine the effect of loading doses of caffeine and if increases in RrSO₂ correlate with improved clinical kidney outcomes.

Impact: Caffeine administration is associated with increased renal tissue oxygenation in preterm neonates with low baseline values under 40%. The most significant renal tissue oxygenation changes occur in the first 3 h after IV caffeine administration. With recent studies suggesting low RrSO₂ values in preterm neonates are associated with AKI, caffeine should be studied as a potential therapeutic for this common and complex morbidity in preterm neonates.