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. 2021;15(2):147-152.
doi: 10.1134/S1990750821020050. Epub 2021 May 14.

Osteogenic and Angiogenic Properties of Heparin as a System for Delivery of Biomolecules for Bone Bioengineering: a Brief Critical Review

L S Litvinova  1 , K A Yurova  1 , O G Khaziakhmatova  1 , M Yu Khlusova  2 , V V Malashchenko  1 , E O Shunkin  1 , N M Todosenko  1 , I K Norkin  1 , P A Ivanov  1 , I A Khlusov  3   4
Affiliations

Osteogenic and Angiogenic Properties of Heparin as a System for Delivery of Biomolecules for Bone Bioengineering: a Brief Critical Review

L S Litvinova et al. Biochem Mosc Suppl B Biomed Chem. 2021.

Abstract

The review considers complex, controversial, and individual effects of heparin and its derivatives on the bone and circulatory systems in dependence of the dose, the state of the cells and tissues of the recipient. General data on the anticoagulant activity of heparin and its derivatives are presented; special attention is paid to the effect of heparin on mesenchymal cells and tissues and its role in angiogenesis. We also discuss the ability of heparin to bind osteogenic and angiogenic biomolecules in the context of the development of systems for their delivery and sustained controlled release and propose a schematic representation of the positive and side effects of heparin as a delivery system for biomolecules in tissue engineering.

Keywords: anticoagulant; bone tissue bioengineering; delivery system; hemostasis system; heparin; regenerative medicine.

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Conflict of interest statement

CONFLICT OF INTERESTSThe authors declare that they have no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Positive and side effects of heparin as a delivery system for biomolecules in tissue engineering. AT-III—antithrombin III; BMP-2—bone morphogenetic protein 2; BMP-4—bone morphogenetic protein 4; BMP-6—bone morphogenetic protein 6; FGF—fibroblast growth factor; OPG, osteoprotegerin; TGF-β—transforming growth factor β-1; VEGF—vascular endothelial growth factor; MSCs are mesenchymal stem cells.
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