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Case Reports
. 2021 May 14;8(5):e00583.
doi: 10.14309/crj.0000000000000583. eCollection 2021 May.

Discordant Pathological and Endoscopic Diagnosis: Consider Floaters

Abby R Sapp  1 , Praneet Wander  1 , Usman Ali  2 , Yulan Gong  3 , Reza V Milano  4 , Michael J Bartel  1
Affiliations
Case Reports

Discordant Pathological and Endoscopic Diagnosis: Consider Floaters

Abby R Sapp et al. ACG Case Rep J. .

Abstract

A tissue floater or extraneous cross-contamination tissue on a microscopic slide is rare; however, it is a potential cause of diagnostic error. Occasionally, on collecting and processing of specimens, cross-contamination of tissue occurs leading to pathologic findings that are inconsistent with endoscopic findings. If the extraneous tissue is neoplastic, it can lead to a false-positive diagnosis. We present a case of discordant pathological and endoscopic diagnosis of invasive squamous carcinoma of the esophagus.

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Figures

Figure 1.
Figure 1.
Blue light imaging no gross nodular abnormality seen.
Figure 2.
Figure 2.
High-definition white light with Lugol's solution.
Figure 3.
Figure 3.
Endoscopic mucosal resection specimen showing normal esophageal and esophagogastric junction mucosa.
Figure 4.
Figure 4.
Normal esophagus including gastroesophageal junction seen along with the detached squamous cell cancer which was interpreted to be a floater.
See this image and copyright information in PMC

References

    1. Platt E, Sommer P, McDonald L, Bennett A, Hunt J. Tissue floaters and contaminants in the histology laboratory. Arch Pathol Lab Med. 2009;133(6):973–8. - PubMed
    1. Layfield LJ, Witt BL, Metzger KG, Anderson GM. Extraneous tissue: A potential source for diagnostic error in surgical pathology. Am J Clin Pathol. 2011;136(5):767–72. - PubMed
    1. Mansour NM, Anandasabapathy S. Lugol's chromoendoscopy in the screening of esophageal squamous cell carcinoma: Time to take a closer look? Clin Gastroenterol Hepatol. 2018;16(10):1562–3. - PubMed
    1. Tsuji N, Ishiguro S, Kudo M. Esophagus with multiple small Lugol's iodine-unstained lesions has high likelihood of developing multicentric esophageal squamous cell carcinoma. Gastroenterology. 2003;124(4):A298.

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