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Case Reports
. 2021 May 14;8(5):e00586.
doi: 10.14309/crj.0000000000000586. eCollection 2021 May.

Infliximab-Induced Acute Liver Failure in a Patient With Crohn's Disease Requiring Orthotopic Liver Transplantation

Muhammed Mustafa Alikhan  1 , Emad Mansoor  2 , Sagarika Satyavada  2 , Katarina Greer  2 , Wei Xin  3 , Stanley Cohen  2 , Gregory Cooper  2 , Jeffry Katz  2
Affiliations
Case Reports

Infliximab-Induced Acute Liver Failure in a Patient With Crohn's Disease Requiring Orthotopic Liver Transplantation

Muhammed Mustafa Alikhan et al. ACG Case Rep J. .

Abstract

Tumor necrosis factor-alpha inhibitors are not known to have significant liver toxicity; however, a few case reports state otherwise. We report the case of a 25-year-old man with Crohn's disease who was initiated on infliximab. The patient developed severe mixed hepatocellular and cholestatic liver injury that progressed into acute liver failure. Based on clinical history, laboratory findings, and histology, this was presumed because of the development of autoimmune hepatitis secondary to infliximab. He underwent liver transplantation. The mainstay of treatment in this rare condition involves steroid therapy and possible transplantation. Patients must then avoid anti-tumor necrosis factor-alpha therapy for life.

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Figures

Figure 1.
Figure 1.
Massive hepatocellular necrosis with infiltration of portal lymphocytic and lymphoplasmacytic cells.
Figure 2.
Figure 2.
Acute hepatitis with massive hepatocellular necrosis.
See this image and copyright information in PMC

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