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Comment
. 2021 Sep;12(9):1540-1541.
doi: 10.1111/jdi.13596. Epub 2021 Jul 4.

Inceptor intercepts insulin signaling in pancreatic β-cells

Hirotaka Watada  1
Affiliations
Comment

Inceptor intercepts insulin signaling in pancreatic β-cells

Hirotaka Watada. J Diabetes Investig. 2021 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

HW discloses honoraria for lectures for Mitsubishi Tanabe Pharma, Dainippon Sumitomo Pharma, Sanwa Kagaku, Takeda, Sanofi, Kowa, Merck Sharp & Dohme, Boehringer Ingelheim, Eli Lilly and Novo Nordisk, and research activities for Takeda, Boehringer Ingelheim, Kissei Pharma, Novo Nordisk, Mitsubishi Tanabe Pharma, Lifescan Japan, Dainippon Sumitomo Pharma, Kyowa Kirin and Merck Sharp & Dohme.

Figures

Figure 1
Figure 1
Inceptor regulates β‐cell function. The signal pathway from insulin and insulin‐like growth factor‐1 receptors has been shown to be essential for the maintenance of normal β‐cell function. Activating protein (AP)‐2 binding protein inceptor enhances internalization of insulin receptor in β‐cells, thus, suppressed expression of inceptor enhances β‐cell function.
See this image and copyright information in PMC

Comment on

  • Inceptor counteracts insulin signalling in β-cells to control glycaemia.
    Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Ansarullah, et al. Nature. 2021 Feb;590(7845):326-331. doi: 10.1038/s41586-021-03225-8. Epub 2021 Jan 27. Nature. 2021. PMID: 33505018

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