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. 2022 Apr;24(4):328-335.
doi: 10.1080/10286020.2021.1923012. Epub 2021 May 19.

Anti-inflammatory sesquiterpene dimers and diterpenes from the aerial part of Inula japonica

Rui-Fang Wu  1   2 , Wen-Qiong Wang  1 , Bing-Duo Zhou  3 , Yi Wang  3 , Ya-Ding Li  3 , Sheng-Liang Zhu  3 , Li-Jiang Xuan  1   2
Affiliations

Anti-inflammatory sesquiterpene dimers and diterpenes from the aerial part of Inula japonica

Rui-Fang Wu et al. J Asian Nat Prod Res. 2022 Apr.

Abstract

Phytochemical investigation on the 95% alcohol extract of the aerial part of Inula japonica led to the isolation of three new compounds, inulanolides F-G (1-2) and 17α-carboxaldehyde-ent-kaur-18-oic acid (3), together with four known compounds (4-7). The structures of new compounds were elucidated by using spectroscopic data. Most of the isolated compounds showed significant anti-inflammatory activities.

Keywords: Anti-inflammation; Inula japonica; composite; ent-kaurane diterpenes; sesquiterpene dimers.

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