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Randomized Controlled Trial
. 2021 Oct;41(10):3313-3323.
doi: 10.1007/s10792-021-01893-z. Epub 2021 May 19.

Various modalities of cyclodestruction in non-refractory glaucoma: a comparative study

Abdussalam Mohsen Abdullatif  1 , Heba Magdy Ahmed El-Saied  2   3
Affiliations
Randomized Controlled Trial

Various modalities of cyclodestruction in non-refractory glaucoma: a comparative study

Abdussalam Mohsen Abdullatif et al. Int Ophthalmol. 2021 Oct.

Abstract

Purpose: The aim of the study is to study the safety and efficacy of three cyclodestructive treatments; high-intensity focused ultrasound (HIFU) cyclocoagulation versus micropulse cyclophotocoagulation (MP-CPC) versus transscleral continuous-wave cyclophotocoagulation (CW-CPC) for treatment of non-refractory glaucoma.

Methods: This is a prospective comparative single-center study. Thirty non-refractory, medically uncontrolled, primary open-angle glaucoma patients with good vision were randomized to a single session of HIFU, MP-CPC or CW-CPC. Intraocular pressure (IOP) reduction, number of medications, success rate, visual acuity and complications were compared between the three groups. Success was defined as an IOP reduction of 30% and IOP between 6 and 21 mmHg with or without medications, in the absence of vision-threatening complications.

Results: Thirty patients were enrolled in our study: 10 patients received HIFU, 10 patients received MP-CPC and 10 patients received CW-CPC. At 6 months, IOP was reduced by 31.5%, 23.9% and 19.4% (P = 0.4) achieving a success rate of 50%, 60% and 50% (P = 0.8) for continuous, micropulse and HFU groups, respectively, with reduction in the number of drops and stop of oral acetazolamide. Although the difference in the rate of complications between groups was not significant, CW-CPC group had more complications.

Conclusions: Cyclophotocoagulation could be an option in the treatment of non-refractory glaucoma even in patients with good visual acuity, with similar outcomes between the three types of cyclodestruction.

Keywords: Continuous-wave; High-intensity frequency ultrasound; Micropulse; Non-refractory glaucoma.

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References

    1. Ansari E, Gandhewar J (2007) Long-term efficacy and visual acuity following transscleral diode laser photocoagulation in cases of refractory and non-refractory glaucoma. Eye 21(7):936–940 - DOI
    1. Bloom PA, Tsai JC, Sharma K et al (1997) “Cyclodiode”: trans-scleral diode laser cyclophotocoagulation in the treatment of advanced refractory glaucoma. Ophthalmology 104(9):1508–1520 - DOI
    1. Hauber FA, Scherer WJ (2002) Influence of total energy delivery on success rate after contact diode laser transscleral cyclophotocoagulation: a retrospective case review and meta-analysis. J Glaucoma 11(4):329–333 - DOI
    1. Egbert PR, Fiadoyor S, Budenz DL, Dadzie P, Byrd S (2001) Diode laser transscleral cyclophotocoagulation as a primary surgical treatment for primary open-angle glaucoma. Arch Ophthalmol 119(3):345–350 - DOI
    1. Benson MT, Nelson ME (1990) Cyclocryotherapy: a review of cases over a 10-year period. Br J Ophthalmol 74(2):103–105 - DOI

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