Low-fluence and low-density CO2 laser: histological analysis of collagen fiber changes in skin and its clinical repercussions in photorejuvenation
- PMID: 34009520
- DOI: 10.1007/s10103-021-03330-0
Low-fluence and low-density CO2 laser: histological analysis of collagen fiber changes in skin and its clinical repercussions in photorejuvenation
Abstract
This study refers to clinical and histologic analysis of effects on photorejuvenation after one single treatment of fractional CO2 laser with low fluence and low density. To analyze histologically the quantitative variation of collagen fibers type I and III, elastic fibers, and epidermal thickness on D84, besides clinical evaluation of amount, length, thickness, and depth of periocular wrinkles during the same period. This is an open, prospective, interventional study. There were 40 healthy female with age between 35 and 65 years. Twenty-six participants were randomly selected for D0 and D84 biopsy. A single session of fractional CO2 laser was done in the hole face, using a 800-µm tip, 5% density, and 10 mJ fluence with a single pass. On D0, D42, and D84, a clinical comparative analysis of amount, length, depth, and thickness of periocular wrinkles has been done. On histological analysis, a comparative quantitative evaluation of collagen fibers type I and III, elastic fibers, and epidermal thickness has been done on D0 and D84. The results of this study denoted a significant clinical improvement of amount (- 32.17%; p < 0.0001), thickness (- 33%; p < 0.0001), lenght (- 35.84%; p < 0.0001), and depth of periocular wrinkles (- 32.46%; p < 0.0001). A significant increase in the amount of collagen fibers type III was observed on D84 (+ 60.67%; p = 0.0013). Collagen fibers type I and elastic fibers did not have the same result, with a nonsignificant increase (+ 8.31%; p = 0.3820) and a decrease (- 12.4%; p = 0.0585) respectively. Epidermal thickness has a tendency to significant variation (p = 0.05553). The results demonstrate that fractional CO2 laser with low fluence and low density is a safe and efficient option for photorejuvenation of the face.
Keywords: Ablative fractional laser; CO2 laser; Photorejuvenation.
© 2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
References
-
- Khan MH, Sink RK, Manstein D, Eimerl D, Anderson RR (2005) Intradermally focused infrared laser pulses: thermal effects at defined tissue depths. Lasers Surg Med 36(4):270–280. https://doi.org/10.1002/lsm.20142 - DOI - PubMed
-
- Prignano F, Bonciani D, Campolmi P, Cannarozzo G, Bonan P, Lotti T (2011) A study of fractional CO2 laser resurfacing: the best fluences through a clinical, histological, and ultrastructural evaluation. J Cosmet Dermatol 10:210–216. https://doi.org/10.1111/j.1473-2165.2011.00571.x - DOI - PubMed
-
- Thomson PJ (2002) Wylie J (2002) Interventional laser surgery: an effective surgical and diagnostic tool in oral precancer management. Int J Oral Maxillofac Surg 31(2):145–153. https://doi.org/10.1054/ijom.2001.0189 - DOI - PubMed
-
- Sharon-Buller A, Sela M (2004) CO2-laser treatment of ulcerative lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97(3):332–334. https://doi.org/10.1016/j.tripleo.2003.11.012 - DOI - PubMed
-
- Motta MM, Stelini RF, Calderoni DR, Gilioli R, Kharmandayan P (2016) Lower energy and pulse stacking. A safer alternative for skin tightening using fractional CO2 laser. Acta Cir Bras 31(1):28–35. https://doi.org/10.1590/S0102-865020160010000005 - DOI - PubMed
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