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. 2021 May:7:734-739.
doi: 10.1200/GO.20.00616.

Survival in Cervical Cancer and Its Predictors at Ocean Road Cancer Institute From January to December 2012

Salama Iddy Khamis  1 , Alita S Mrema  1 , Johnson Katanga  1   2 , Emmanuel L Lugina  1   2
Affiliations

Survival in Cervical Cancer and Its Predictors at Ocean Road Cancer Institute From January to December 2012

Salama Iddy Khamis et al. JCO Glob Oncol. 2021 May.

Abstract

Purpose: In Tanzania, cancer of cervix is the most commonly diagnosed cancer and is the leading cause of cancer-related deaths. There are very little data about survival of patients with cervical cancer after treatment in Tanzania. The aims of this study were to determine 5-year overall survival (OS) rate and its predictors among patients with cervical cancer treated at Ocean Road Cancer Institute (ORCI) from January to December 2012.

Materials and methods: This was retrospective study done at ORCI by reviewing medical charts of 202 patients with cervical cancer treated at ORCI from January to December 2012. A structured questionnaire was used to extract information about characteristics of the respondents. Survival curves were estimated by using Kaplan-Meir analysis and were compared by using log-rank test.

Results: The 5-year OS rate was 26%. The mean and median survival times were 33.9 and 19 months, respectively. Factors that were positively associated with 5-year OS rate include the hemoglobin level more than 9 g/dL at presentation, early International Federation of Gynecology and Obstetrics stage at presentation, high dose of radiotherapy, and use of concurrent chemoradiotherapy. Histology type and HIV status were not associated with survival.

Conclusion: The 5-year overall survival rate was 26%. Predictors of OS were hemoglobin level, stage at presentation, radiotherapy dose, and the use of concurrent chemoradiotherapy.

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Conflict of interest statement

The following represents disclosure information provided by the authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO’s conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/go/authors/author-center.

Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).

No potential conflicts of interest were reported.

Figures

FIG 1
FIG 1
The OS of patients with cervical cancer. OS, overall survival.
FIG 2
FIG 2
The association between OS rate and Hb level. Hb, hemoglobin; OS, overall survival.
FIG 3
FIG 3
The association between OS rate and FIGO stage. FIGO, International Federation of Gynecology and Obstetrics; OS, overall survival.
FIG 4
FIG 4
The association between OS rate and radiotherapy dose. EBRT, external beam radiotherapy; OS, overall survival.
FIG 5
FIG 5
The association between OS rate and type of histology. ADC, adenocarcinoma; OS, overall survival; SCC, squamous cell carcinoma.
FIG 6
FIG 6
The association between OS rate and the use of concurrent chemoradiotherapy. OS, overall survival.
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin 68394–4242018 - PubMed
    1. Pérez A, Santamaria EK, Operario D, et al. IARC Handbook of Cance Prevention BMC Public Health 51–82017
    1. Wabinga HR, Nambooze S, Amulen PM, et al. Trends in the incidence of cancer in Kampala, Uganda 1991-2010 Int J Cancer 135432–4392014 - PubMed
    1. Anorlu RI.Cervical cancer: The sub-Saharan African perspective Reprod Health Matters 1641–492008 - PubMed
    1. Sengayi-Muchengeti M, Joko-Fru WY, Miranda-Filho A, et al. Cervical cancer survival in sub-Saharan Africa by age, stage at diagnosis and Human Development Index: A population-based registry study Int J Cancer 1473037–30482020 - PubMed

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