Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

David C Bishop^{1

2

3

4}, Leighton E Clancy^{1

5}, Renee Simms^{1

2

5}, Jane Burgess^{1

2

5}, Geetha Mathew^{1

5}, Leili Moezzi^{1

5}, Janine A Street^{1

5}, Gaurav Sutrave^{1

2

3

4}, Elissa Atkins³, Helen M McGuire^{6

7

8}, Brian S Gloss¹, Koon Lee^{1

2}, Wei Jiang^{1

2}, Karen Maddock³, Georgia McCaughan^{2

3}, Selmir Avdic^{1

5}, Vicki Antonenas⁵, Tracey A O'Brien^{9

10

11}, Peter J Shaw^{12

13}, David O Irving^{14

15}, David J Gottlieb^{1

2

3

4

5}, Emily Blyth^{1

2

3

4

5}, Kenneth P Micklethwaite^{1

2

3

4

5}

Affiliations

¹ Westmead Institute for Medical Research, Sydney, NSW, Australia.
² Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
³ Department of Haematology , Westmead Hospital, Sydney, NSW, Australia.
⁴ Blood Transplant and Cell Therapies Program, Westmead Hospital, Sydney, NSW, Australia.
⁵ Blood Transplant and Cell Therapies Laboratory, NSW Health Pathology-ICPMR Westmead, Sydney, NSW, Australia.
⁶ Ramaciotti Facility for Human Systems Biology, University of Sydney, Sydney, NSW, Australia.
⁷ Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
⁸ School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.
⁹ Children's Cancer Institute, Sydney, NSW, Australia.
¹⁰ School of Women's & Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
¹¹ Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, Australia.
¹² BMT Services, Children's Hospital at Westmead, Sydney, NSW, Australia.
¹³ Discipline of Child and Adolescent Health, The Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
¹⁴ Australian Red Cross Lifeblood, Sydney, NSW, Australia; and.
¹⁵ Faculty of Nursing, Midwifery & Health, University of Technology, Sydney, NSW, Australia.

PMID: 34010392
DOI: 10.1182/blood.2021010813

Free article

Clinical Trial

Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

David C Bishop et al. Blood. 2021.

Free article

. 2021 Oct 21;138(16):1504-1509.

doi: 10.1182/blood.2021010813.

Authors

Affiliations

¹ Westmead Institute for Medical Research, Sydney, NSW, Australia.
² Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
³ Department of Haematology , Westmead Hospital, Sydney, NSW, Australia.
⁴ Blood Transplant and Cell Therapies Program, Westmead Hospital, Sydney, NSW, Australia.
⁵ Blood Transplant and Cell Therapies Laboratory, NSW Health Pathology-ICPMR Westmead, Sydney, NSW, Australia.
⁶ Ramaciotti Facility for Human Systems Biology, University of Sydney, Sydney, NSW, Australia.
⁷ Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
⁸ School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.
⁹ Children's Cancer Institute, Sydney, NSW, Australia.
¹⁰ School of Women's & Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
¹¹ Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, Australia.
¹² BMT Services, Children's Hospital at Westmead, Sydney, NSW, Australia.
¹³ Discipline of Child and Adolescent Health, The Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
¹⁴ Australian Red Cross Lifeblood, Sydney, NSW, Australia; and.
¹⁵ Faculty of Nursing, Midwifery & Health, University of Technology, Sydney, NSW, Australia.

PMID: 34010392
DOI: 10.1182/blood.2021010813

No abstract available

PubMed Disclaimer

Comment in

Two cases of T cell lymphoma following Piggybac-mediated CAR T cell therapy.
Schambach A, Morgan M, Fehse B. Schambach A, et al. Mol Ther. 2021 Sep 1;29(9):2631-2633. doi: 10.1016/j.ymthe.2021.08.013. Epub 2021 Aug 24. Mol Ther. 2021. PMID: 34433080 Free PMC article. No abstract available.
Expect the unexpected: piggyBac and lymphoma.
Wilson MH, Gottschalk S. Wilson MH, et al. Blood. 2021 Oct 21;138(16):1379-1380. doi: 10.1182/blood.2021012349. Blood. 2021. PMID: 34673949 No abstract available.

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
- Silverchair Information Systems
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

Affiliations

Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

Authors

Affiliations

Comment in

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical