Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May 21;100(20):e25728.
doi: 10.1097/MD.0000000000025728.

Evaluation of efficacy and safety of endovascular coiling for patients with aneurysmal subarachnoid hemorrhage: A protocol for systematic review and meta-analysis

Qiu-Rong Fu  1 , Yan Wang, Shi-Bu Lin, Yan Yang
Affiliations

Evaluation of efficacy and safety of endovascular coiling for patients with aneurysmal subarachnoid hemorrhage: A protocol for systematic review and meta-analysis

Qiu-Rong Fu et al. Medicine (Baltimore). .

Abstract

Background: There is an elevated risk of rebleeding when the aneurysm is left untreated in patients diagnosed with aneurysmal subarachnoid hemorrhage (SAH). Occlusion of the lumen of the aneurysm using endovascular coiling is a common method to prevent rebleeding by occluding the aneurysm. This study aims to evaluate the efficacy and safety of endovascular coiling in patients with aneurysmal SAH.

Methods: A systematic search for relevant articles will be performed in 4 English electronic databases, including MEDLINE (from 1966 to October 2020), EMBASE (from 1980 to October 2020), the Cochrane Library (from 2020, issue 10), Scopus (from 1823 to October 2020), and 3 Chinese electronic databases, including Chinese Biomedical Literature Database (from 1995 to October 2020), WanFang (last searched October 2020), and China National Knowledge Infrastructure (last searched October 2020). This study will comprise randomized controlled trials (RCTs) that evaluate the effectiveness and safety of using endovascular coiling in the treatment of aneurysmal SAH. The articles in the databases will be independently screened by 2 authors to select potential studies, extract data, and evaluate the bias risk in the selected studies. This study will use suitable statistical methods to merge result data.

Results: The results of this study will be useful in determining the efficacy and safety of endovascular coiling for treating patients with aneurysmal SAH.

Conclusion: The findings of this study will summarize the most recent evidence on the effectiveness and safety of using endovascular coiling to treat aneurysmal SAH.

Ethics and dissemination: The present work does not involve any humans or animals; therefore, ethical approval is not needed.

Systematic review registration: December 2, 2020.osf.io/yj4gq (https://osf.io/yj4gq/).

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interests to disclose.

Figures

Figure 1
Figure 1
The research flowchart.
See this image and copyright information in PMC

References

    1. Connolly ES, Jr, Rabinstein AA, Carhuapoma JR, et al. . Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2012;43:1711–37. - PubMed
    1. de Rooij NK, Linn FH, van der Plas JA, et al. . Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends. J Neurol Neurosurg Psychiatry 2007;78:1365–72. - PMC - PubMed
    1. Miller BA, Turan N, Chau M, et al. . Inflammation, vasospasm, and brain injury after subarachnoid hemorrhage. Biomed Res Int 2014;2014:384342. - PMC - PubMed
    1. Güresir E, Vasiliadis N, Konczalla J, et al. . Erythropoietin prevents delayed hemodynamic dysfunction after subarachnoid hemorrhage in a randomized controlled experimental setting. J Neurol Sci 2013;332:128–35. - PubMed
    1. de Oliveira Manoel AL, Turkel-Parrella D, Duggal A, et al. . Managing aneurysmal subarachnoid hemorrhage: it takes a team. Cleve Clin J Med 2015;82:177–92. - PubMed

MeSH terms

LinkOut - more resources