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Editorial
. 2021 Aug 1;106(8):2040-2041.
doi: 10.3324/haematol.2021.279186.

A new enemy is emerging in the fight against the SARS-CoV-2 pandemic

Francesco Rodeghiero  1 , Carlo L Balduini  2
Affiliations
Editorial

A new enemy is emerging in the fight against the SARS-CoV-2 pandemic

Francesco Rodeghiero et al. Haematologica. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Of the 49 patients with vaccine-induced immune thrombotic thrombocytopenia reported to date, 79% were women and only 4% were over 60 years old. The risk of this disease, therefore, seems to be extremely low in old people who, on the other hand, have a high risk of death from SARS-CoV-2. The administration of adenoviral vaccines against SARS-CoV-2 is therefore highly advantageous in this category of subjects. Conversely, vaccine-induced immune thrombotic thrombocytopenia (VITT) seems to be more common in young or middle-aged adults, especially women, who instead have a risk of death from SARS-CoV-2 much lower and in some age categories even close to zero. Pending new data, these considerations have convinced some countries not to administer adenoviral vaccines to young subjects.
See this image and copyright information in PMC

Comment on

  • Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia.
    Althaus K, Möller P, Uzun G, Singh A, Beck A, Bettag M, Bösmüller H, Guthoff M, Dorn F, Petzold GC, Henkes H, Heyne N, Jumaa H, Kreiser K, Limpach C, Luz B, Maschke M, Müller JA, Münch J, Nagel S, Pötzsch B, Müller J, Schlegel C, Viardot A, Bäzner H, Wolf M, Pelzl L, Warm V, Willinek WA, Steiner J, Schneiderhan-Marra N, Vollherbst D, Sachs UJ, Fend F, Bakchoul T. Althaus K, et al. Haematologica. 2021 Aug 1;106(8):2170-2179. doi: 10.3324/haematol.2021.279000. Haematologica. 2021. PMID: 34011137 Free PMC article.
  • Post-mortem findings in vaccine-induced thrombotic thombocytopenia.
    Pomara C, Sessa F, Ciaccio M, Dieli F, Esposito M, Garozzo SF, Giarratano A, Prati D, Rappa F, Salerno M, Tripodo C, Zamboni P, Mannucci PM. Pomara C, et al. Haematologica. 2021 Aug 1;106(8):2291-2293. doi: 10.3324/haematol.2021.279075. Haematologica. 2021. PMID: 34011138 Free PMC article. No abstract available.

References

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    1. Schultz NH, Sørvoll IH, Michelsen AE, et al. . Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination. N Engl J Med. 2021;384(22):2124-2130. - PMC - PubMed
    1. Scully M, Singh D, Lown R, et al. . Pathologic antibodies to platelet factor 4 after ChAdOx1 nCoV-19 vaccination. N Engl J Med. 2021;384(23):2202-2211. - PMC - PubMed
    1. Althaus K, Möller P, Uzun G, et al. . Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia. Haematologica. 2021;106(8):2170-2179. - PMC - PubMed
    1. Pomara C, Sessa F, Ciaccio M, et al. . Post-mortem findings in vaccineinduced Thrombotic Thombocytopenia. Haematologica. 2021;106(8)2291-2293. - PMC - PubMed

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