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Review
. 2021 May 19;59(6):e02335-20.
doi: 10.1128/JCM.02335-20. Print 2021 May 19.

The Brief Case: Disseminated Microsporidiosis with Intestinal Cryptosporidium Coinfection in a Patient with Kaposi's Sarcoma and Castleman Disease Presenting with Acute Kidney Injury

Apeksha N Agarwal  1 , Wun-Ju Shieh  2 , Cynthia S Goldsmith  2 , Yvonne Qvarnstrom  3 , Yanli Ding  4 , Steven D Dallas  4 , Daniel D Mais  4
Affiliations
Review

The Brief Case: Disseminated Microsporidiosis with Intestinal Cryptosporidium Coinfection in a Patient with Kaposi's Sarcoma and Castleman Disease Presenting with Acute Kidney Injury

Apeksha N Agarwal et al. J Clin Microbiol. .
No abstract available

Keywords: Encephalitozoon intestinalis; acute kidney injury; microsporidium.

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Figures

FIG 1
FIG 1
(A) Gram stain of sputum showing Gram-positive spores (arrow) with belt-like stripe; ×1,000 magnification, oil immersion. (B) Sputum calcofluor white stain showing multiple fluorescent ovoid spores (arrow) of microsporidia; ×400 magnification. (C) Kidney biopsy specimen showing lymphohistiocytic infiltration in the interstitium (arrow, histiocyte). Hematoxylin and eosin (H&E) stain; ×400 magnification. (D) Lillie-Twort Gram stain of kidney biopsy specimen showing small ovoid Gram-positive organisms (arrow) in the tubules; ×400 magnification. (E) Gram stain of kidney biopsy specimen showing ovoid Gram-positive organisms (arrow); ×400 magnification. (F) Gram stain of kidney biopsy specimen at higher magnification showing Gram-positive spores (arrow); ×1,000 magnification. (G) Gomori methenamine silver (GMS) stain showing small ovoid organisms in the tubules; ×400 magnification. (H) Kidney biopsy specimen showing immunostaining of abundant microsporidia (arrow) in the tubules and interstitium; ×400 magnification.
FIG 2
FIG 2
(A) Electron microscopy of renal biopsy specimen showing a parasitophorous vacuole with degenerated microsporidia in different stages of development separated by septae. (B) Electron microscopy of renal biopsy specimen showing seven coils of polar tubule in microsporidium.
See this image and copyright information in PMC

References

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