doi: 10.1016/0006-291x(88)90195-7.
Vitamin E inhibits protein kinase C activity
Affiliations
- PMID: 3401229
- DOI: 10.1016/0006-291x(88)90195-7
Item in Clipboard
Vitamin E inhibits protein kinase C activity
Biochem Biophys Res Commun.
.
Abstract
Vitamin E (dl-alpha-tocopherol) has been found to inhibit in vitro brain protein kinase c with a half inhibitory concentration of 450 microM. The known plasma concentrations of vitamin E are one order of magnitude lower than the protein kinase c half-inhibitory concentration but it is also known that, at the membrane level where the active protein kinase c is located, the lipophilic vitamin E is more concentrated (Burton, G.W., Joyce, A. and Ingold, K.U. and Locke, S. (1983) Arch. Biochem. Biophys. 221, 281-290). It appears that vitamin E, in addition to its antioxidant function, may play a role in regulating the activity of protein kinase c.
Similar articles
-
dl-alpha-tocopherol, a potent inhibitor of phorbol ester induced shape change of erythro- and megakaryoblastic leukemia cells.J Cell Physiol. 1997 Sep;172(3):351-60. doi: 10.1002/(SICI)1097-4652(199709)172:3<351::AID-JCP9>3.0.CO;2-N. J Cell Physiol. 1997. PMID: 9284955
-
RRR-alpha-tocopherol regulation of gene transcription in response to the cell oxidant status.Z Ernahrungswiss. 1998;37 Suppl 1:21-8. Z Ernahrungswiss. 1998. PMID: 9558725
-
Vitamin E inhibits platelet phospholipase A2.Biochim Biophys Acta. 1986 May 21;876(3):639-45. doi: 10.1016/0005-2760(86)90053-6. Biochim Biophys Acta. 1986. PMID: 3707988
-
Vitamin E: beyond antioxidant function.Am J Clin Nutr. 1995 Dec;62(6 Suppl):1501S-1509S. doi: 10.1093/ajcn/62.6.1501S. Am J Clin Nutr. 1995. PMID: 7495251 Review.
-
Vitamin E inhibition of platelet aggregation is independent of antioxidant activity.J Nutr. 2001 Feb;131(2):374S-7S. doi: 10.1093/jn/131.2.374S. J Nutr. 2001. PMID: 11160564 Review.
Cited by
-
Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection.J Lipid Res. 2013 Sep;54(9):2307-14. doi: 10.1194/jlr.R026641. Epub 2013 Mar 15. J Lipid Res. 2013. PMID: 23505320 Free PMC article. Review.
-
Antioxidant vitamins and their use in preventing cardiovascular disease.Molecules. 2010 Nov 9;15(11):8098-110. doi: 10.3390/molecules15118098. Molecules. 2010. PMID: 21063272 Free PMC article. Review.
-
Mitochondria: a new therapeutic target in chronic kidney disease.Nutr Metab (Lond). 2015 Nov 25;12:49. doi: 10.1186/s12986-015-0044-z. eCollection 2015. Nutr Metab (Lond). 2015. PMID: 26612997 Free PMC article. Review.
-
Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs.Genes Nutr. 2024 Mar 12;19(1):5. doi: 10.1186/s12263-024-00739-4. Genes Nutr. 2024. PMID: 38475720 Free PMC article. Review.
-
Modulation of ozone-sensitive genes in alpha-tocopherol transfer protein null mice.Inhal Toxicol. 2010 Jan;22(1):1-16. doi: 10.3109/08958370902838145. Inhal Toxicol. 2010. PMID: 19555225 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
