Going sugar free: Treg cells avoid glucose to maintain functional fitness
- PMID: 34013589
- DOI: 10.1111/imcb.12461
Going sugar free: Treg cells avoid glucose to maintain functional fitness
Comment on
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CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours.Nature. 2021 Mar;591(7851):652-658. doi: 10.1038/s41586-021-03326-4. Epub 2021 Feb 15. Nature. 2021. PMID: 33588426 Free PMC article.
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Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.Nature. 2021 Mar;591(7851):645-651. doi: 10.1038/s41586-020-03045-2. Epub 2021 Feb 15. Nature. 2021. PMID: 33589820 Free PMC article.
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- Fischer K, Hoffmann P, Voelkl S, et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 2007; 109: 3812-3819.
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- Michalek RD, Gerriets VA, Jacobs SR, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol 2011; 186: 3299-3303.
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