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Comment
. 2021 Jul 5;218(7):e20210531.
doi: 10.1084/jem.20210531. Epub 2021 May 20.

CD1a autoreactivity: When size does matter

Laurent Gapin  1   2
Affiliations
Comment

CD1a autoreactivity: When size does matter

Laurent Gapin. J Exp Med. .

Abstract

CD1a-autoreactive T cells represent a significant proportion of circulating αβ T cells in humans and appear to be enriched in the skin. How their autoreactivity is regulated remains unclear. In this issue of JEM, Cotton et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202699) show that CD1a molecules do not randomly survey cellular lipids but instead capture certain lipid classes that broadly interfere with the binding of autoreactive T cell antigen receptors to the target CD1a. These findings provide new potential therapeutic avenues for manipulating CD1a autoreactive T cell responses.

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References

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