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. 2022 Mar 1;74(4):715-718.
doi: 10.1093/cid/ciab465.

Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

Alana F Ogata  1   2   3 , Chi-An Cheng  1   2   3 , Michaël Desjardins  3   4   5 , Yasmeen Senussi  1 , Amy C Sherman  3   4 , Megan Powell  4 , Lewis Novack  4 , Salena Von  4 , Xiaofang Li  6 , Lindsey R Baden  3   4   6 , David R Walt  1   2   3
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Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

Alana F Ogata et al. Clin Infect Dis. .

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Eleven of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of immunoglobulin G (IgG) and immunoglobulin A (IgA).

Keywords: COVID-19; SARS-CoV-2 antigens; immune responses; mRNA vaccine; spike.

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