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Comment
. 2021 May 19;109(10):1593-1595.
doi: 10.1016/j.neuron.2021.04.027. Epub 2021 May 12.

Fast-Trk(B)ing the mechanism of antidepressants

Jacinta N Conroy  1 , Dhanisha J Jhaveri  2 , Elizabeth J Coulson  3
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Free article
Comment

Fast-Trk(B)ing the mechanism of antidepressants

Jacinta N Conroy et al. Neuron. .
Free article

Abstract

The mechanism by which antidepressants elicit clinical improvements has proven elusive. In a recent publication in Cell, Casarotto et al. (2021) reveal a surprising direct interaction between antidepressants and TrkB. This link provides an important mechanistic insight into synaptic remodeling that may assist in the design of improved antidepressant therapeutics.

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  • Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
    Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E. Casarotto PC, et al. Cell. 2021 Mar 4;184(5):1299-1313.e19. doi: 10.1016/j.cell.2021.01.034. Epub 2021 Feb 18. Cell. 2021. PMID: 33606976 Free PMC article.

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