The Individualized Powerhouse: Mitofusin-2 Regulates Nucleus Accumbens Mitochondrial Influence on Individual Differences in Trait Anxiety

Affiliations

¹ Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
² Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: mklobo@som.umaryland.edu.

Comment

Cali A Calarco et al. Biol Psychiatry. 2021.

. 2021 Jun 1;89(11):1024-1026.

doi: 10.1016/j.biopsych.2021.03.031.

¹ Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland.
² Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address: mklobo@som.umaryland.edu.

No abstract available

Comment on

Mitofusin-2 in the Nucleus Accumbens Regulates Anxiety and Depression-like Behaviors Through Mitochondrial and Neuronal Actions.
Gebara E, Zanoletti O, Ghosal S, Grosse J, Schneider BL, Knott G, Astori S, Sandi C. Gebara E, et al. Biol Psychiatry. 2021 Jun 1;89(11):1033-1044. doi: 10.1016/j.biopsych.2020.12.003. Epub 2020 Dec 8. Biol Psychiatry. 2021. PMID: 33583561

1. Gebara E, Zanoletti O, Ghosal S, Grosse J, Schneider BL, Knott G, et al. (2021): Mitofusin-2 in the nucleus accumbens regulates anxiety and depression-like behaviors through mitochondrial and neuronal actions. Biol Psychiatry 89:1033–1044. - PubMed
1. Fox ME, Lobo MK (2019): The molecular and cellular mechanisms of depression: A focus on reward circuitry. Mol Psychiatry 24:1798–1815. - PMC - PubMed
1. Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, et al. (2016): Circuit-wide transcriptional profiling reveals brain region-specific gene networks regulating depression susceptibility. Neuron 90:969–983. - PMC - PubMed
1. Filiou MD, Sandi C (2019): Anxiety and brain mitochondria: A bidirectional crosstalk. Trends Neurosci 42:573–588. - PubMed
1. Russo SJ, Dietz DM, Dumitriu D, Morrison JH, Malenka RC, Nestler EJ (2010): The addicted synapse: Mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci 33:267–276. - PMC - PubMed