Inflammatory stromal cells in the myeloma microenvironment

Romanos Sklavenitis-Pistofidis^#^{1

2

3}, Nicholas J Haradhvala^#^{3

4}, Gad Getz^{3

5}, Irene M Ghobrial^{6

7

8}

Affiliations

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
² Center for Prevention of Progression of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA, USA.
³ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁴ Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA, USA.
⁵ Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁶ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. irene_ghobrial@dfci.harvard.edu.
⁷ Center for Prevention of Progression of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA, USA. irene_ghobrial@dfci.harvard.edu.
⁸ Broad Institute of MIT and Harvard, Cambridge, MA, USA. irene_ghobrial@dfci.harvard.edu.

^# Contributed equally.

PMID: 34017125
DOI: 10.1038/s41590-021-00947-9

Comment

Inflammatory stromal cells in the myeloma microenvironment

Romanos Sklavenitis-Pistofidis et al. Nat Immunol. 2021 Jun.

. 2021 Jun;22(6):677-678.

doi: 10.1038/s41590-021-00947-9.

Authors

Romanos Sklavenitis-Pistofidis^#^{1

2

3}, Nicholas J Haradhvala^#^{3

4}, Gad Getz^{3

5}, Irene M Ghobrial^{6

7

8}

Affiliations

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
² Center for Prevention of Progression of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA, USA.
³ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁴ Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA, USA.
⁵ Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁶ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. irene_ghobrial@dfci.harvard.edu.
⁷ Center for Prevention of Progression of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA, USA. irene_ghobrial@dfci.harvard.edu.
⁸ Broad Institute of MIT and Harvard, Cambridge, MA, USA. irene_ghobrial@dfci.harvard.edu.

^# Contributed equally.

PMID: 34017125
DOI: 10.1038/s41590-021-00947-9

No abstract available

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Comment on

The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape.
de Jong MME, Kellermayer Z, Papazian N, Tahri S, Hofste Op Bruinink D, Hoogenboezem R, Sanders MA, van de Woestijne PC, Bos PK, Khandanpour C, Vermeulen J, Moreau P, van Duin M, Broijl A, Sonneveld P, Cupedo T. de Jong MME, et al. Nat Immunol. 2021 Jun;22(6):769-780. doi: 10.1038/s41590-021-00931-3. Epub 2021 May 20. Nat Immunol. 2021. PMID: 34017122 Clinical Trial.

References

1. Dhodapkar, M. V. Blood 128, 2599–2606 (2016). - DOI
1. Das, R. et al. Nat. Med. 22, 1351–1357 (2016). - DOI
1. Zavidij, O. et al. Nat. Cancer 1, 493–506 (2020). - DOI
1. Reagan, M. R. & Ghobrial, I. M. Clin. Cancer Res. 18, 342–349 (2011). - DOI
1. de Jong, M. E. M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00931-3 (2021). - DOI - PubMed

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Inflammatory stromal cells in the myeloma microenvironment

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Inflammatory stromal cells in the myeloma microenvironment

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