Cortical auditory neuron interactions during presentation of 3-tone sequences: effective connectivity

Abstract

The role of cat's primary auditory cortex (AI) in both pattern discrimination and sound localization has been demonstrated by observing that ablations of it disrupt these functions. This research studied effective connectivity variations as a function of modifications in the temporal pattern of acoustic stimulation. Recordings of 10-15 neurons (simultaneously and separably) were made in AI of sedated cats. A bundle of 7 microelectrodes was stereotaxically placed along a tangential path. Stimuli were permutations of 3-tone bursts sequences. Each recorded neuron pair was analyzed off-line by cross-correlation. Cross-correlation of spike trains from neuron pairs showed signatures of direct and/or shared input. These appeared individually or in combination and for most pairs were present in spontaneous conditions. However, in stimulated conditions these spontaneous interactions were strongly modulated. The analysis detected differences in neuronal interaction during presentation of different tones. Similar differences occurred during presentation of any single particular stimulus if there was a history of different immediately previous tones. When individual neuron pair cross-correlations were put together to form an effective connectivity diagram among all recorded neurons, they turned out as different diagrams for different stimulus conditions.