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. 2021 Apr 15;13(4):2883-2890.
eCollection 2021.

Correlation between the levels of NLRP3, Hcy, IL-1β, IL-18 and the prognosis in patients with hemorrhagic stroke

Qingyong Li  1 , Zhiheng Zhao  2 , Kun Si  1 , Jianguo Zhou  1 , Li'na Du  1 , Hua Liu  1 , Ru Lin  3
Affiliations

Correlation between the levels of NLRP3, Hcy, IL-1β, IL-18 and the prognosis in patients with hemorrhagic stroke

Qingyong Li et al. Am J Transl Res. .

Abstract

Objective: To explore the connection of nucleotide-binding oligomerization domain-like receptors 3 (NLRP3), homocysteine (Hcy), interleukin-1β (IL-1β), interleukin-18 (IL-18) in peripheral blood and prognosis in patients with hemorrhagic stroke.

Methods: A total of 84 patients with hemorrhagic stroke treated in our hospital were selected and divided into the good prognosis group (48 cases) and the poor prognosis group (36 cases) according to the Glasgow Prognostic Scale (GOS) at month 6 after discharge. 40 people who were matched for age, sex and risk factors for cerebral hemorrhage, but did not have cerebral hemorrhage, were selected as a control group. We detected the levels of NLRP3, Hcy, IL-1β and IL-18 in peripheral blood, and analyzed their correlation with GOS score. Then we performed Logistic regression analysis to investigate the risk factors for poor prognosis.

Results: The expressions of NLRP3 mRNA, Hcy, IL-1β and IL-18 in peripheral blood in the poor prognosis group were higher than those in the good prognosis group (P<0.05). The expression levels of NLRP3 mRNA, Hcy, IL-1β and IL-18 were negatively correlated with GOS scores (P<0.05). Regression analysis showed that the expression of NLRP3 mRNA, serum Hcy, bleeding volume and ventricular system penetration were independent risk factors for poor prognosis.

Conclusion: In patients with poor prognosis of hemorrhagic stroke, the mRNA levels of NLRP3 and serum Hcy, IL-1β and IL-18 levels in peripheral blood elevated. High NLRP3 mRNA levels, Hcy levels, bleeding volume and ventricle system penetration are independent risk factors for poor prognosis.

Keywords: Hemorrhagic stroke; homocysteine; inflammasome; interleukin-18; interleukin-1β; nucleotide-binding oligomerization domain-like receptors 3.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
The correlation of NLRP3 mRNA expression and the GOS score mRNA. NLRP3: nucleotide-binding oligomerization domain-like receptors 3; GOS: glasgow outcome scale.
Figure 2
Figure 2
The correlation of serum Hcy and the GOS score. Hcy: homocysteine; GOS: glasgow outcome scale.
Figure 3
Figure 3
The correlation of serum IL-1β and the GOS score. IL-1β: interleukin-1β; GOS: glasgow outcome scale.
Figure 4
Figure 4
The correlation of serum IL-18 and the GOS score. IL-18: interleukin-18; GOS: glasgow outcome scale.
See this image and copyright information in PMC

References

    1. Zhang XT, Zhou Y, Zhang S, Ding WH, Lou M. Cerebral blood flow evaluation of intensive rosuvastatin therapy in stroke/transient ischemic attack patients with intracranial arterial atherosclerotic stenosis study: rationale and design. Brain Behav. 2017;7:e00689. - PMC - PubMed
    1. Frontera JA, Starling R, Cho SM, Nowacki AS, Uchino K, Hussain MS, Mountis M, Moazami N. Risk factors, mortality and timing of ischemic and hemorrhagic stroke with left ventricular assist devices. J Heart Lung Transplant. 2016;36:673–683. - PubMed
    1. Chen LC, Chen MH, Su TP, Tsai S, Bai YM, Li CT, Yang AC, Chang WH, Chen TJ. Atopic diseases/diathesis and subsequent ischemic stroke among patients with bipolar disorder: a nationwide longitudinal study. PLoS One. 2018;13:e0200682. - PMC - PubMed
    1. Al-Khaled M, Eggers J. Prognosis of intracerebral hemorrhage after conservative treatment. J Stroke Cerebrovasc Dis. 2014;23:230–234. - PubMed
    1. Archana H, Jamil D, Eugene A, Patel A, Samant R, Yaghi S. Nosocomial infections in patients with spontaneous intracerebral hemorrhage. Am J Crit Care. 2015;24:227–231. - PubMed

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