Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 15;13(4):2947-2954.
eCollection 2021.

The clinical significance of changes in cTnT, CRP and NT-proBNP levels in patients with heart failure

Qingsong Wang  1 , Yu An  1 , Hong Wang  1 , Na Zhang  1 , Shuai Deng  2
Affiliations

The clinical significance of changes in cTnT, CRP and NT-proBNP levels in patients with heart failure

Qingsong Wang et al. Am J Transl Res. .

Abstract

Objective: This study was designed to explore the clinical significance of changes in troponin T (cTnT), C-reactive protein (CRP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with heart failure (HF).

Methods: A total of 193 patients with HF admitted to our hospital from October 2013 to June 2019 were enrolled as the study subjects (group A). Another 191 healthy controls were included as group B. Both groups were compared in terms of cTnT, CRP, NT-proBNP levels and left ventricular ejection fraction (LVEF), and the correlations between LVEF and cTnT, CRP, NT-proBNP were analyzed. The differences in cTnT, CRP, NT-proBNP were compared among patients with different cardiac function, different causes of HF, and between patients with and without cardiac events.

Results: cTnT, CRP, and NT-proBNP levels in group A were higher than those in group B (P<0.05). LVEF in group A was lower than that in group B (P<0.05). Negative correlations were found between CRP, cTnT, NT-proBNP and LVEF (P<0.05). As cardiac function improved, cTnT, CRP, NT-proBNP levels also increased, with significant differences between groups (P<0.05). cTnT, CRP, and NT-proBNP levels exhibited no significant difference between the ischemic and non-ischemic HF groups (P>0.05). Patients with cardiac events showed higher levels of cTnT, CRP, and NT-proBNP than those without cardiac events (P<0.05).

Conclusion: cTnT, CRP and NT-proBNP levels were elevated in patients with HF, which were negatively correlated with LVEF, and their levels increased with the improvement of cardiac function, independent of the cause of HF. The combination of these three indices is of great significance in the diagnosis and prognosis of HF.

Keywords: C-reactive protein; Heart failure; amino-terminal brain natriuretic peptide precursor; clinical significance; troponin T.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of cTnT, CRP and NT-proBNP levels between groups A and B. A. showed that the CRP level of group A was higher than that of group B, P<0.05; B. showed that the cTnT level of group A was higher than that of group B, P<0.05; C. showed that the level of NT-proBNP in group A was higher than that in group B, P<0.05. * indicates a comparison with group B, P<0.05.
Figure 2
Figure 2
Comparison of the measured values of various indices in patients with heart failure of varying classes. A. showed that the cTnT level of NYHA class II, III, and IV was higher than that of class I, P<0.05; B. showed that the CRP level in patients with NYHA class II, III, and IV was higher than that in patients with class I heart failure, P<0.05; C. showed that NT-proBNP levels of patients with NYHA class II, III, and IV were higher than patients with class I, P<0.05. * indicates a comparison with Class I, P<0.05.
Figure 3
Figure 3
Comparison of the measured values of each index in patients with heart failure of different etiologies. A. TnT levels. B. CRP levels. C. NT-proBNP levels.
Figure 4
Figure 4
Comparison of the measured values of each index between patients with cardiac events and those without cardiac events. A. cTnT levels; B. NT-proBNP levels; C. CRP levels. * indicates a comparison with patients without cardiac events, P<0.05.
See this image and copyright information in PMC

References

    1. Dupuy AM, Curinier C, Kuster N, Huet F, Leclercq F, Davy JM, Cristol JP, Roubille F. Multi-marker strategy in heart failure: combination of ST2 and CRP predicts poor outcome. PLoS One. 2016;11:e0157159. - PMC - PubMed
    1. Demissei BG, Cotter G, Prescott MF, Felker GM, Filippatos G, Greenberg BH, Pang PS, Ponikowski P, Severin TM, Wang Y, Qian M, Teerlink JR, Metra M, Davison BA, Voors AA. A multimarker multi-time point-based risk stratification strategy in acute heart failure: results from the RELAX-AHF trial. Eur J Heart Fail. 2017;19:1001–1010. - PubMed
    1. Ohkuma T, Jun M, Woodward M, Zoungas S, Cooper ME, Grobbee DE, Hamet P, Mancia G, Williams B, Welsh P, Sattar N, Shaw JE, Rahimi K, Chalmers J. Cardiac stress and inflammatory markers as predictors of heart failure in patients with type 2 diabetes: the ADVANCE trial. Diabetes Care. 2017;40:1203–1209. - PMC - PubMed
    1. Schwermer K, Hoppe K, Radziszewska D, Kłysz P, Sawatiuk P, Nealis J, Kałużna M, Kaczmarek J, Baum E, Lindholm B, Pawlaczyk K, Oko A. N-terminal pro-B-type natriuretic peptide as a marker of hypervolemia and predictor of increased mortality in patients on hemodialysis. Pol Arch Med Wewn. 2015;125:560–569. - PubMed
    1. Ahmad T, Fiuzat M, Mark DB, Neely B, Neely M, Kraus WE, Kitzman DW, Whellan DJ, Donahue M, Zannad F, Piña IL, Adams K, O’Connor CM, Felker GM. The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure. Am Heart J. 2014;167:193–202. e191. - PMC - PubMed