Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 15;13(4):3443-3450.
eCollection 2021.

Detailed nursing intervention on neonatal septicemia can improve the clinical symptoms of children and reduce the inflammatory reaction

Jing Wang  1 , Peifen Li  1 , Peijie Zhang  2 , Qing Du  1
Affiliations

Detailed nursing intervention on neonatal septicemia can improve the clinical symptoms of children and reduce the inflammatory reaction

Jing Wang et al. Am J Transl Res. .

Abstract

Objective: To explore the application effect of detailed nursing intervention in neonatal septicemia.

Methods: Altogether 60 neonates of neonatal septicemia admitted to our hospital from November 2019 to October 2020 were selected as the research participants, and all the children have received routine treatment, among which 30 neonates received routine nursing intervention as the regular group, and the remaining 30 received detailed nursing intervention as the detail group. The clinical effects, improvement of clinical symptoms, length of stay, and guardian satisfaction were compared, and the levels of serum inflammatory factors (TNF-α, IL-6 and IL-17) and immune function indicators (CD4+, CD8+) before and after nursing intervention were detected.

Results: The total effective rate in the detail group was higher than that in the regular group (P < 0.05). Compared with the regular group, the temperature stabilization time, blood culture turning negative time, improvement time of milk rejection and hospital stay in the detail group were significantly shortened (P < 0.05). The guardian satisfaction score in the detail group was higher than that in the regular group (P < 0.05). After nursing, the levels of TNF-α, IL-6 and IL-17 decreased in both groups, and the levels of these three in the detail group were lower than those in the regular group (P < 0.05). After nursing, CD4+/CD8+ of children in both groups increased, and CD4+/CD8+ in the detail group and regular group were higher than those in the regular group (P < 0.05).

Conclusion: The adoption of detailed nursing modes in the treatment of neonatal septicemia can further improve the treatment effect, shorten the hospital stay and the improvement time of clinical symptoms, reduce the incidence of complications, improve the nursing satisfaction of guardians, reduce the inflammation of the body and improve the immune function of the body.

Keywords: Detail nursing; immunologic function; inflammation; neonatal septicemia.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of TNF-α, IL-6 and IL-17 levels between two groups of children before and after nursing. A: After treatment, the serum TNF-α level of children in both groups decreased, and the level of TNF-α in the detail group was lower than that in the regular group. B: After treatment, the serum IL-6 level of children in both groups decreased, and the level of IL-6 in the detail group was lower than that in the regular group. C: After treatment, the serum IL-17 level of children in both groups decreased, and the level of IL-17 in the detail group was lower than that in the regular group. Note: * indicates compared with before nursing, P < 0.05; # indicates compared with the regular group, P < 0.05.
Figure 2
Figure 2
Comparison of CD4+, CD8+ and CD4+/CD8+ levels of children before and after nursing. A: The CD4+ level of children in both groups increased after treatment, and the CD4+ level in the detail group was higher than that in the regular group. B: CD8+ levels of children in both groups decreased after treatment, and CD8+ levels in the detail group were lower than those in the regular group. C: After treatment, CD4+/CD8+ in both groups increased, and CD4+/CD8+ in the detail group was higher than that in the regular group. Note: * indicates compared with before nursing, P < 0.05; # indicates compared with the regular group, P < 0.05.
See this image and copyright information in PMC

References

    1. Chaurasia S, Sivanandan S, Agarwal R, Ellis S, Sharland M, Sankar MJ. Neonatal sepsis in South Asia: huge burden and spiralling antimicrobial resistance. BMJ. 2019;364:k5314. - PMC - PubMed
    1. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–171. - PMC - PubMed
    1. Wynn JL. Defining neonatal sepsis. Curr Opin Pediatr. 2016;28:135–140. - PMC - PubMed
    1. Ganesan P, Shanmugam P, Sattar SB, Shankar SL. Evaluation of IL-6, CRP and hs-CRP as early markers of neonatal sepsis. J Clin Diagn Res. 2016;10:DC13–17. - PMC - PubMed
    1. Boettiger M, Tyer-Viola L, Hagan J. Nurses’ early recognition of neonatal sepsis. J Obstet Gynecol Neonatal Nurs. 2017;46:834–845. - PubMed

LinkOut - more resources