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. 2021 Apr 15;13(4):3487-3493.
eCollection 2021.

The effect of controlling the heart rate on the heart failure index and on heart function in heart failure patients with atrial fibrillation

Huawei Tian  1 , Yuping Li  1 , Jun Zhang  1 , Chao Cheng  1
Affiliations

The effect of controlling the heart rate on the heart failure index and on heart function in heart failure patients with atrial fibrillation

Huawei Tian et al. Am J Transl Res. .

Abstract

Objective: To explore the effect of controlling the heart rate on the heart failure index and on heart function in patients with heart failure and atrial fibrillation.

Methods: 82 patients with heart failure and atrial fibrillation were divided into a control group (n=41) and a study group (n=41). The patients in the control group underwent conventional treatment. In addition to the conventional treatment, the patients in the study group were administered metoprolol to actively control their heart rates and to decrease their resting heart rates down to 55-60 beats/min as the target heart rate. After three months of treatment, the heart function, the levels of N terminal pro B type natriuretic peptide (NT-proBNP), and the inflammatory factors were compared between the two groups. At the same time, the readmission rates and prognoses were calculated.

Results: After the treatment, the left ventricular ejection fraction (LVEF) and the cardiac output (CO) levels in the two groups were increased, and the levels in the study group were higher than the levels in the control group; there were opposite trends in the left ventricular end-systolic diameter (LVESD) levels, the left ventricular end-diastolic dimension (LVEDD) levels, and the NT-proBNP, serum CRP, TNF-α and IL-6 levels (all P<0.05). After a six month follow up, the readmission and heart failure rates, and the incidence of adverse events in the study group were lower than they were in the control group (all P<0.05).

Conclusion: The effective control of the ventricular rate can more significantly benefit the heart failure symptoms and atrial fibrillation, alleviate the inflammatory response, and thus improve the heart function and prognoses of heart failure patients with atrial fibrillation.

Keywords: Heart rate control; atrial fibrillation; heart failure; heart function.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of the NT-proBNP levels before and after the treatment in the patients in the two groups. NT-proBNP: N-terminal pro-brain natriuretic peptide. Compared with before the treatment, *P<0.05; compared with the control group, #P<0.05.
Figure 2
Figure 2
Comparison of the readmission rates between the two groups during the follow-up. Compared with the control group, #P<0.05.
See this image and copyright information in PMC

References

    1. Marrouche NF, Brachmann J, Andresen D, Siebels J, Boersma L, Jordaens L, Merkely B, Pokushalov E, Sanders P, Proff J, Schunkert H, Christ H, Vogt J, Bänsch D. Catheter ablation for atrial fibrillation with heart failure. N Engl J Med. 2018;378:417–427. - PubMed
    1. Kotecha D, Piccini JP. Atrial fibrillation in heart failure: what should we do? Eur Heart J. 2015;36:3250–3257. - PMC - PubMed
    1. Ruddox V, Sandven I, Munkhaugen J, Skattebu J, Edvardsen T, Otterstad JE. Atrial fibrillation and the risk for myocardial infarction, all-cause mortality and heart failure: a systematic review and meta-analysis. Eur J Prev Cardiol. 2017;24:1555–1566. - PMC - PubMed
    1. Richter S, Di Biase L, Hindricks G. Atrial fibrillation ablation in heart failure. Eur Heart J. 2019;40:663–671. - PubMed
    1. Brown L, Karmakar C, Gray R, Jindal R, Lim T, Bryant C. Heart rate variability alterations in late life depression: a meta-analysis. J Affect Disord. 2018;235:456–466. - PubMed

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