Sweat Testing and Recent Advances
- PMID: 34017807
- PMCID: PMC8129525
- DOI: 10.3389/fped.2021.649904
Sweat Testing and Recent Advances
Abstract
Cystic fibrosis (CF) is the most common fatal genetic disease of the Caucasian population. Sweat testing is the principal diagnostic test for CF, and it is used for the evaluation of infants with positive CF newborn screening (NBS) and in patients with clinical findings suggesting CF. This article describes the classical sweat test method in detail and also provides an overwiew of recent advances.
Keywords: Gibson-Cooke; chloride; cystic fibrosis; diagnosis; sweat test.
Copyright © 2021 Gokdemir and Karadag.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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References
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- Gibson LE, Cooke RE. A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics. (1959) 23:545–9. - PubMed
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- CLSI . Sweat testing: specimen collection and quantitative chloride analysis. CLSI Guideline C34. 4th ed. Wayne, PA: Clinical and Laboratory Standards Institute; (2019).
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