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. 1988 Jun 1;469(1-2):303-7.
doi: 10.1016/0165-3806(88)90192-7.

Cross-species grafting of embryonic mouse and grafting of older postnatal rat retinas into the lesioned adult rat eye: the importance of cyclosporin A for survival

R Aramant  1 , J E Turner
Affiliations

Cross-species grafting of embryonic mouse and grafting of older postnatal rat retinas into the lesioned adult rat eye: the importance of cyclosporin A for survival

R Aramant et al. Brain Res. .

Abstract

Embryonic day-15 mouse retinas were grafted into an adult rat retinal lesion site and allowed to survive for 9 and 30 days. Grafted animals received either no Cyclosporin A treatment, treatment for the first 10 days of transplantation or continuous treatment. In a second experimental set up, postnatal day-21 rat retinas were grafted under the same conditions and received either no Cyclosporin A administration, treatment during the first 24 h or continuous treatment over a 6-day survival period. Our results show that continuous Cyclosporin A treatment is necessary for successful cross-species grafting as well as to maintain for some time partly viable day-21 rat retinal grafts.

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