Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jul;88(7):690-695.
doi: 10.1007/s12098-021-03766-w. Epub 2021 May 20.

Recent Advances in Bronchopulmonary Dysplasia

Vivek V Shukla  1 , Namasivayam Ambalavanan  2   3
Affiliations
Review

Recent Advances in Bronchopulmonary Dysplasia

Vivek V Shukla et al. Indian J Pediatr. 2021 Jul.

Abstract

Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease that occurs in preterm infants, usually those receiving substantial respiratory support with either mechanical ventilation or supplementation with oxygen. The pathogenesis of BPD is multifactorial, and the clinical phenotype is variable. BPD is associated with substantial mortality and short- and long-term morbidity. The incidence of BPD has remained stable or increased, as advances in neonatal care have led to improved survival of more extremely preterm infants. Extensive basic science, translational, and clinical research focusing on BPD has improved the current understanding of the factors that contribute to BPD pathogenesis. However, despite a better understanding of its pathophysiology, BPD continues to be challenging to prevent and manage adequately. The current review aims to provide a clinically useful synopsis of evidence on the prevention and management of BPD in preterm infants.

Keywords: Bronchopulmonary dysplasia; Oxidative stress; Pulmonary hypertension; Respiratory distress syndrome; Volutrauma.

PubMed Disclaimer

References

    1. Schittny JC. Development of the lung. Cell Tissue Res. 2017;367:427–44.
    1. Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967;276:357–68.
    1. Thebaud B, Goss KN, Laughon M, et al. Bronchopulmonary dysplasia. Nat Rev Dis Primers. 2019;5:78.
    1. Ambalavanan N, Cotten CM, Page GP, et al. Genomics and cytokine subcommittees of the eunice kennedy shriver national institute of child health and human development neonatal research network. Integrated genomic analyses in bronchopulmonary dysplasia. J Pediatr. 2015;166:531–7 e13.
    1. Lal CV, Ambalavanan N. Genetic predisposition to bronchopulmonary dysplasia. Semin Perinatol. 2015;39:584–91.

LinkOut - more resources