Protein S-Palmitoylation and Lung Diseases

doi:10.1007/978-3-030-68748-9_10

. 2021:1304:165-186.

doi: 10.1007/978-3-030-68748-9_10.

Protein S-Palmitoylation and Lung Diseases

Zeang Wu^#^{1

2

3}, Rubin Tan^#^{3

4}, Liping Zhu³, Ping Yao⁵, Qinghua Hu⁶

Affiliations

¹ School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China.
³ School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁴ School of Basic Medicine, Xuzhou Medical University, Xuzhou, China.
⁵ School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. yaoping@mails.tjmu.edu.cn.
⁶ School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. qinghuaa@mails.tjmu.edu.cn.

^# Contributed equally.

PMID: 34019269
DOI: 10.1007/978-3-030-68748-9_10

Protein S-Palmitoylation and Lung Diseases

Zeang Wu et al. Adv Exp Med Biol. 2021.

. 2021:1304:165-186.

doi: 10.1007/978-3-030-68748-9_10.

Authors

Zeang Wu^#^{1

2

3}, Rubin Tan^#^{3

4}, Liping Zhu³, Ping Yao⁵, Qinghua Hu⁶

Affiliations

¹ School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China.
³ School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁴ School of Basic Medicine, Xuzhou Medical University, Xuzhou, China.
⁵ School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. yaoping@mails.tjmu.edu.cn.
⁶ School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. qinghuaa@mails.tjmu.edu.cn.

^# Contributed equally.

PMID: 34019269
DOI: 10.1007/978-3-030-68748-9_10

Abstract

S-palmitoylation of protein is a posttranslational, reversible lipid modification; it was catalyzed by a family of 23 mammalian palmitoyl acyltransferases in humans. S-palmitoylation can impact protein function by regulating protein sorting, secretion, trafficking, stability, and protein interaction. Thus, S-palmitoylation plays a crucial role in many human diseases including mental illness and cancers. In this chapter, we systematically reviewed the influence of S-palmitoylation on protein performance, the characteristics of S-palmitoylation regulating protein function, and the role of S-palmitoylation in pulmonary inflammation and pulmonary hypertension and summed up the treatment strategies of S-palmitoylation-related diseases and the research status of targeted S-palmitoylation agonists/inhibitors. In conclusion, we highlighted the potential role of S-palmitoylation and depalmitoylation in the treatment of human diseases.

Keywords: Depalmitoylation; Protein modification; S-palmitoylation; zDHHC.

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References

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1. McMichael TM, Zhang L, Chemudupati M, Hach JC, Kenney AD, Hang HC, et al. The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity. J Biol Chem. 2017;292(52):21517–26. - PubMed - PMC - DOI

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[1] Jiang H, Zhang X, Chen X, Aramsangtienchai P, Tong Z, Lin H. Protein Lipidation: occurrence, mechanisms, biological functions, and enabling technologies. Chem Rev. 2018;118(3):919–88. - PubMed - PMC - DOI

[2] Jiang H, Zhang X, Chen X, Aramsangtienchai P, Tong Z, Lin H. Protein Lipidation: occurrence, mechanisms, biological functions, and enabling technologies. Chem Rev. 2018;118(3):919–88. - PubMed - PMC - DOI

[3] Linder ME, Deschenes RJ. Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol. 2007;8(1):74–84. - PubMed - DOI - PMC

[4] Linder ME, Deschenes RJ. Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol. 2007;8(1):74–84. - PubMed - DOI - PMC

[5] Cao N, Li JK, Rao YQ, Liu H, Wu J, Li B, et al. A potential role for protein palmitoylation and zDHHC16 in DNA damage response. BMC Mol Biol. 2016;17(1):12. - PubMed - PMC - DOI

[6] Cao N, Li JK, Rao YQ, Liu H, Wu J, Li B, et al. A potential role for protein palmitoylation and zDHHC16 in DNA damage response. BMC Mol Biol. 2016;17(1):12. - PubMed - PMC - DOI

[7] Ho GP, Selvakumar B, Mukai J, Hester LD, Wang Y, Gogos JA, et al. S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron. 2011;71(1):131–41. - PubMed - PMC - DOI

[8] Ho GP, Selvakumar B, Mukai J, Hester LD, Wang Y, Gogos JA, et al. S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron. 2011;71(1):131–41. - PubMed - PMC - DOI

[9] McMichael TM, Zhang L, Chemudupati M, Hach JC, Kenney AD, Hang HC, et al. The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity. J Biol Chem. 2017;292(52):21517–26. - PubMed - PMC - DOI

[10] McMichael TM, Zhang L, Chemudupati M, Hach JC, Kenney AD, Hang HC, et al. The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity. J Biol Chem. 2017;292(52):21517–26. - PubMed - PMC - DOI

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Protein S-Palmitoylation and Lung Diseases

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