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Comment
. 2021 May 20;81(10):2059-2060.
doi: 10.1016/j.molcel.2021.04.024.

A molecular Rosetta Stone to decipher the impact of chromatin features on the repair of Cas9-mediated DNA double-strand breaks

Pierre Caron  1 , Enrico Pobega  1 , Sophie E Polo  2
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Comment

A molecular Rosetta Stone to decipher the impact of chromatin features on the repair of Cas9-mediated DNA double-strand breaks

Pierre Caron et al. Mol Cell. .
Free article

Abstract

Using a barcoded reporter introduced within a thousand different chromatin locations in human cells, (Schep et al., 2021) characterize repair outcomes of Cas9-induced DNA double-strand breaks (DSBs) and the relative use of DSB repair pathways depending on the local chromatin context.

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