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. 2021 Aug:184:106435.
doi: 10.1016/j.rmed.2021.106435. Epub 2021 May 15.

Residual ground glass opacities three months after Covid-19 pneumonia correlate to alteration of respiratory function: The post Covid M3 study

Justine Frija-Masson  1 , Marie-Pierre Debray  2 , Samia Boussouar  3 , Antoine Khalil  2 , Catherine Bancal  4 , Justina Motiejunaite  5 , Maria Alejandra Galarza-Jimenez  6 , Hélène Benzaquen  4 , Dominique Penaud  4 , Pierantonio Laveneziana  7 , Roxane Malrin  8 , Alban Redheuil  3 , Victoria Donciu  9 , Olivier Lucidarme  10 , Camille Taillé  11 , Antoine Guerder  8 , Florence Arnoult  4 , Emmanuelle Vidal-Petiot  12 , Martin Flamant  12 , Thomas Similowski  13 , Capucine Morelot-Panzini  13 , Morgane Faure  13 , François-Xavier Lescure  14 , Christian Straus  7 , Marie-Pia d'Ortho  5 , Jésus Gonzalez-Bermejo  8
Affiliations

Residual ground glass opacities three months after Covid-19 pneumonia correlate to alteration of respiratory function: The post Covid M3 study

Justine Frija-Masson et al. Respir Med. 2021 Aug.

Abstract

Introduction: Lung function in survivors of SARS-Co-V2 pneumonia is poorly known, but concern over the possibility of sequelae exists.

Methods: Retrospective study on survivors with confirmed infection and pneumonia on chest-CT. Correlations between PFT and residual radiologic anomalies at three months taking into account initial clinical and radiological severity and steroid use during acute phase.

Results: 137 patients (69 men, median age 59 (Q1 50; Q3 68), BMI 27.5 kg/m2 (25.1; 31.7)) were assessed. Only 32.9% had normal PFT, 75 had altered DLCO. Median (Q1; Q3) values were: VC 79 (66; 92) % pred, FEV1 81 (68; 89), TLC 78 (67; 85), DLCO 60 (44; 72), and KCO 89 (77; 105). Ground glass opacities (GGO) were present in 103 patients (75%), reticulations in 42 (30%), and fibrosis in 18 (13%). There were significantly lower FEV1 (p = 0.0089), FVC (p = 0.0010), TLC (p < 0.0001) and DLCO (p < 0.0001) for patients with GGO, lower TLC (p = 0.0913) and DLCO (p = 0.0181) between patients with reticulations and lower FVC (p = 0.0618), TLC (p = 0.0742) DLCO (p = 0.002) and KCO (p = 0.0114) between patients with fibrosis. Patients with initial ≥50% lung involvement had significantly lower FEV1 (p = 0.0019), FVC (p = 0.0033), TLC (p = 0.0028) and DLCO (p = 0.0003) compared to patients with ≤10%. There was no difference in PFT and residual CT lesions between patients who received steroids and those who did not.

Conclusion: The majority of patients have altered PFT at three months, even in patients with mild initial disease, with significantly lower function in patients with residual CT lesions. Steroids do not seem to modify functional and radiological recovery. Long-term follow-up is needed.

Keywords: ARDS; COVID-19; Chest CT; Invasive ventilation; Pneumonia; SARS-CoV-2; TLCO; Vital capacity.

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Figures

Fig. 1
Fig. 1
Study flow chart.
Fig. 2
Fig. 2
Interpretation of pulmonary function test at three months in all patients (panel A) and severity of diffusion capacity alteration (according to ERS standards [16]) in patients with altered DLCO, with or without restriction.
See this image and copyright information in PMC

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References

    1. Jonhs Hopkins University of Medicine New cases of covid-19 in world countries. https://coronavirus.jhu.edu/data/new-cases n.d.
    1. Chen Q., Zheng Z., Zhang C., Zhang X., Wu H., Wang J., Wang S., Zheng C. Infection; Zhejiang, China: 2020. Clinical Characteristics of 145 Patients with Corona Virus Disease 2019 (COVID-19) in Taizhou. - DOI - PMC - PubMed
    1. The Lille COVID-19 ICU. Anatomopathology Group. Copin M.-C., Parmentier E., Duburcq T., Poissy J., Mathieu D. Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med. 2020 doi: 10.1007/s00134-020-06057-8. - DOI - PMC - PubMed
    1. Recalde B., García-Tobar L., Argueta A., Álvarez L., De Andrea C.E., Fernández Alonso M., Ezponda A., Carmona Torre F., Jordán Iborra C., Quiroga J.A., Del Pozo J.L., Zulueta J.J., Echarri G., Landecho M.F., Lozano M.D. Thorax; 2020. Histopathological Findings in Fatal COVID-19 Severe Acute Respiratory Syndrome: Preliminary Experience from a Series of 10 Spanish Patients. - DOI - PubMed
    1. Hui D.S., Joynt G.M., Wong K.T., Gomersall C.D., Li T.S., Antonio G., Ko F.W., Chan M.C., Chan D.P., Tong M.W., Rainer T.H., Ahuja A.T., Cockram C.S., Sung J.J.Y. Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Thorax. 2005;60:401–409. doi: 10.1136/thx.2004.030205. - DOI - PMC - PubMed